DMAPT-DTCs-1,3-diaminopropane-DTCs-DMAPT dimethanesulfonate
DMAPT-DTCs-1,3-diaminopropane-DTCs-DMAPT dimethanesulfonate is an orally active prodrug of MMB-DTCs-1,3-diaminopropane-DTCs-MMB (HY-182917). DMAPT-DTCs-1,3-diaminopropane-DTCs-DMAPT dimethanesulfonate induces apoptosis, ferroptosis, and cuproptosis in lung cancer cells. DMAPT-DTCs-1,3-diaminopropane-DTCs-DMAPT dimethanesulfonate can be used in the research of lung cancer.
For research use only. We do not sell to patients.
- Formula: C41H68N4O12S6
- Molecular Weight:1001.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
DMAPT-DTCs-1,3-diaminopropane-DTCs-DMAPT dimethanesulfonate (Compound 92) exhibits selective anti-proliferative activity against NCI-H820 lung adenocarcinoma cells (IC50 = 0.86 μM) with reduced potency against normal 3T3 fibroblasts (IC50 = 1.83 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
DMAPT-DTCs-1,3-diaminopropane-DTCs-DMAPT dimethanesulfonate (20-100 mg/kg; p.o., i.p.; once every 2 days; for 17 consecutive days) exhibits anti-lung cancer activity in lung adenocarcinoma PDX models by inducing apoptosis, ferroptosis and cuproptosis[1].
DMAPT-DTCs-1,3-diaminopropane-DTCs-DMAPT dimethanesulfonate (20-500 mg/kg; oral administration, intraperitoneal injection; single dose) shows no obvious in vivo toxicity at oral doses up to 500 mg/kg and intraperitoneal doses up to 50 mg/kg, with only mild toxicity observed at an intraperitoneal dose of 100 mg/kg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice (female, n=7 per group; subcutaneous inoculation of 5 × 106 NCI-H820 cells)[1]
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Dosage:20 mg/kg; 50 mg/kg
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Administration:i.p.; every 2 days; 19 days
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Result:Significantly reduced tumor volume and tumor weight compared to controls, without affecting mouse body weight.
Decreased tumor tissue levels of anti-apoptotic protein Bcl-2, ferroptosis-related protein GPX4, and cuproptosis-related proteins FDX1 and DLAT significantly.
Increased pro-apoptotic protein Bax significantly.
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Animal Model:Balb/c nude mice (n=6 per group; subcutaneous inoculation of 3−5 mm3 patient-derived lung adenocarcinoma tissue)[1]
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Dosage:50 mg/kg (p.o.); 100 mg/kg (p.o.); 20 mg/kg (i.p.); 50 mg/kg (i.p.)
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Administration:p.o.; every 2 days; 17 days; i.p.; every 2 days; 17 days
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Result:Reduced tumor volume and tumor weight compared to controls at all tested doses, without affecting mouse body weight.
Decreased tumor tissue levels of anti-apoptotic protein Bcl-2, ferroptosis-related protein GPX4, and cuproptosis-related proteins FDX1 and DLAT significantly.
Increased pro-apoptotic protein Bax significantly.
Showed superior efficacy via intraperitoneal administration compared to oral administration.
Chemical Information
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Molecular Weight 1001.39
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Formula C41H68N4O12S6
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SMILES
S=C(SC/C1=C/CC[C@]2(C)[C@@H](O2)[C@@H](OC([C@H]3CN(C)C)=O)[C@H]3CC1)NCCCNC(SC/C4=C/CC[C@]5(C)[C@@H](O5)[C@@H](OC([C@H]6CN(C)C)=O)[C@@H]6CC4)=S.O=S(C)(O)=O.O=S(C)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DMAPT-DTCs-1,3-diaminopropane-DTCs-DMAPT dimethanesulfonate Related Classifications
HY-182918 Related Classifications
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