2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. DX600

DX600 is a selective ACE2 specific inhibitor (KD: 1.3 nM), and does not cross-react with ACE. DX600 exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

DX600 Chemical Structure

DX600 Chemical Structure

CAS No. : 478188-26-0

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Other Forms of DX600:

DX600 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE DX600

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DX600 is a selective ACE2 specific inhibitor (KD: 1.3 nM), and does not cross-react with ACE. DX600 exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity[1][2][3].

In Vitro

DX600 (1 μM) inhibits rhACE2 activity by 47%, with a pIC50 of 8.0[4].
DX600 (10 μM) inhibits ACE2 activity by 42% in human MNCs (mononuclear cells)[4].
DX600 (100 nM, 4 h) decreases NR 8383 cell growth and increase in TNF-a and IL-6 content in the supernatant (in the presence of LPS and osthole)[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DX600 Related Antibodies
In Vivo

DX600 (5 μg/kg/day, i.p., daily for 4 weeks) exacerbates diabetes-induced cardiovascular dysfunction in Streptozotocin (HY-13753)-treated diabetes rats[2].
DX600 (0.1 µmol/L/kg, i.v ) increases thrombus weight by 30% in thrombosis model in rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: STZ-treated diabetes rats[2]
Dosage: 5 μg/kg/day
Administration: i.p., daily for 4 weeks
Result: Increased cardiac and renal NOX activity.
Molecular Weight

3074.33

Formula

C141H185N35O40S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Gly-Asp-Tyr-Ser-His-Cys-Ser-Pro-Leu-Arg-Tyr-Tyr-Pro-Trp-Trp-Lys-Cys-Thr-Tyr-Pro-NH2 ( Disulfide bridge: Cys6-Cys17)
Sequence Shortening

Ac-GDYSHCSPLRYYPWWKCTYPDPEGGG-NH2 ( Disulfide bridge: Cys6-Cys17)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (16.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3253 mL 1.6264 mL 3.2527 mL
5 mM 0.0651 mL 0.3253 mL 0.6505 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (16.26 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.3253 mL 1.6264 mL 3.2527 mL 8.1319 mL
5 mM 0.0651 mL 0.3253 mL 0.6505 mL 1.6264 mL
10 mM 0.0325 mL 0.1626 mL 0.3253 mL 0.8132 mL
15 mM 0.0217 mL 0.1084 mL 0.2168 mL 0.5421 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DX600 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DX600478188-26-0DX 600DX-600Angiotensin-converting Enzyme (ACE)renin-angiotensin,systemacutelunginjurydiabetesSTZInhibitorinhibitorinhibit

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