478188-26-0
Chemical Structure
DX600
- CAS No.: 478188-26-0
- Formula:C141H185N35O40S2
- Molecular Weight:3074.33
InChIKey: VNWKTOKETHGBQD-UHFFFAOYSA-N
SMILES: O=C(C1([H])N(CCC1)C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C2([H])N(CCC2)C([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@@H](NC3=O)CC4=CNC5=CC=CC=C45)=O)CCCCN)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC6=CC=C(C=C6)O)C(N7[C@@H](CCC7)C(N[C@@H](CC(O)=O)C(N8[C@@H](CCC8)C(N[C@@H](CCC(O)=O)C(NCC(NCC(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CC(O)=O)NC(CNC(C)=O)=O)=O)CC9=CC=C(C=C9)O)=O)=O)CC%10=CN=CN%10)=O)=O)CO)=O)=O)CC(C)C)=O)CCCNC(N)=N)=O)CC%11=CC=C(C=C%11)O)=O)CC%12=CC=C(C=C%12)O)=O)N[C@H]3CC%13=CNC%14=CC=CC=C%13%14
Biological Activity: DX600 is a selective ACE2 specific inhibitor (KD: 1.3 nM), and does not cross-react with ACE. DX600 exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DX600 | 99.71% | DX600 is a selective ACE2 specific inhibitor (KD: 1.3 nM), and does not cross-react with ACE. DX600 exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity. | ||||||||||||||||||||
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- [1]. Liao K, et al. Development of an enzymatic assay for the detection of neutralizing antibodies against therapeutic angiotensin-converting enzyme 2 (ACE2).J Immunol Methods. 2013 Mar 29;389(1-2):52-60. [Content Brief]
- [2]. Yousif MH, et al. Characterization of Angiotensin-(1-7) effects on the cardiovascular system in an experimental model of type-1 diabetes. Pharmacol Res. 2012 Sep;66(3):269-75. [Content Brief]
- [3]. Svilenov HL, et al. Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting SARS-CoV-2. Commun Biol. 2023 Apr 8;6(1):386. [Content Brief]
Keywords
