(E)-2'-Hydroxy-3,4,4',6'-tetramethoxychalcone
(E)-2'-Hydroxy-3,4,4',6'-tetramethoxychalcone is a chalcone derivative that interacts with Hsp90.
For research use only. We do not sell to patients.
- CAS No.: 114021-60-2
- Formula: C19H20O6
- Molecular Weight:344.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
27.6 μM
Compound: 1b
|
Antiproliferative activity against human HCT116 cells after 48 hrs by SRB assay
Antiproliferative activity against human HCT116 cells after 48 hrs by SRB assay
|
[PMID: 30041135] |
| MDCK-II | IC50 |
0.53 μM
Compound: 25
|
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry
|
[PMID: 22112540] |
| Neutrophil | IC50 |
78 μM
Compound: 18
|
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
|
[PMID: 33006891] |
| Neutrophil | IC50 |
74 μM
Compound: 18
|
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
|
[PMID: 33006891] |
Chemical Information
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CAS No. 114021-60-2
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Molecular Weight 344.36
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Formula C19H20O6
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SMILES
COC(C=C1/C=C/C(C2=C(C=C(C=C2O)OC)OC)=O)=C(C=C1)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)