EGFR/ErbB-2 inhibitor-1
EGFR/ErbB-2 inhibitor-1 is a ErbB2/HER2 inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 1135150-79-6
- Formula: C23H15ClFN3OS2
- Molecular Weight:467.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
ErbB2/HER2[1]
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BT-474 | IC50 |
3.22 μM
Compound: 33
|
Antiproliferative activity against human BT474 cells expressing ErbB2 after 72 hrs by CTG assay
Antiproliferative activity against human BT474 cells expressing ErbB2 after 72 hrs by CTG assay
|
[PMID: 19111461] |
| HFF | IC50 |
9.72 μM
Compound: 33
|
Antiproliferative activity against HFF after 72 hrs by CTG assay
Antiproliferative activity against HFF after 72 hrs by CTG assay
|
[PMID: 19111461] |
| HN5 | IC50 |
10.08 μM
Compound: 33
|
Antiproliferative activity against human HN5 cells expressing EGFR after 72 hrs by CTG assay
Antiproliferative activity against human HN5 cells expressing EGFR after 72 hrs by CTG assay
|
[PMID: 19111461] |
Chemical Information
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CAS No. 1135150-79-6
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Molecular Weight 467.97
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Formula C23H15ClFN3OS2
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SMILES
FC1=CC=CC(COC2=CC=C(NC3=C4C=C(C5=CC=CS5)SC4=NC=N3)C=C2Cl)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)