1. Saccharides and Glycosides
  2. Emodin 6-O-β-D-glucoside

Emodin 6-O-β-D-glucoside (Synonyms: Glucoemodin)

Cat. No.: HY-N8126
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Emodin-6-O-β-D-glucoside (Glucoemodin) is an active compound from Reynoutria japonica. Emodin-6-O-β-D-glucoside shows potent anti-inflammatory and barrier protective effects. Emodin-6-O-β-D-glucoside can be used for the research of diabetic complications and atherosclerosis.

For research use only. We do not sell to patients.

Emodin 6-O-β-D-glucoside Chemical Structure

Emodin 6-O-β-D-glucoside Chemical Structure

CAS No. : 34298-85-6

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Description

Emodin-6-O-β-D-glucoside (Glucoemodin) is an active compound from Reynoutria japonica. Emodin-6-O-β-D-glucoside shows potent anti-inflammatory and barrier protective effects. Emodin-6-O-β-D-glucoside can be used for the research of diabetic complications and atherosclerosis[1].

In Vitro

Emodin-6-O-β-D-glucoside (0~20 μM; 24 hours; HUVECs) does not affect cell viability[1].
Emodin-6-O-β-D-glucoside (0~10 μM; 6 hours; HUVECs) results in a dose dependent decrease in high glucose-mediated membrane disruption, inhibits high glucose-induced increase expression of VCAM-1, ICAM-1 and E-selectin and results in decreased expression levels of high glucose-induced MCP-1 and IL-8 mRNA[1].
Emodin-6-O-β-D-glucoside (10 μM; 6 hours; HUVECs) results in a decrease in the number of THP-1 cells adhering to high glucose-induced HUVECs[1].
Emodin-6-O-β-D-glucoside pretreatment significantly inhibits high-glucose-induced ROS formation and p65 NF-κB expression levels increase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HUVECs
Concentration: 0~20 μM
Incubation Time: 24 hours
Result: Did not affect cell viability.

Western Blot Analysis[1]

Cell Line: HUVECs
Concentration: 0~10 μM
Incubation Time: 6 hours
Result: Inhibited high glucose-induced increase expression of VCAM-1, ICAM-1 and E-selectin.

RT-PCR[1]

Cell Line: HUVECs
Concentration: 0~10 μM
Incubation Time: 6 hours
Result: Resulted in decreased expression levels of high glucose-induced MCP-1 and IL-8 mRNA.

Immunofluorescence[1]

Cell Line: HUVECs
Concentration: 10 μM
Incubation Time: 6 hours
Result: Resulted in a decrease in the number of THP-1 cells adhering to high glucose-induced HUVECs.
In Vivo

Emodin-6-O-β-D-glucoside (0~9 mg/mouse; i.v.) markly inhibits peritoneal leakage of dye induced by high glucose[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse[1]
Dosage: 0~9 mg/mouse
Administration: I.v.
Result: Markly inhibited peritoneal leakage of dye induced by high glucose.
Molecular Weight

432.38

Formula

C₂₁H₂₀O₁₀

CAS No.
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Product Name:
Emodin 6-O-β-D-glucoside
Cat. No.:
HY-N8126
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