Enlicitide northern fragment 4
Enlicitide northern fragment 4 is a key intermediate obtained via the retrosynthetic disconnection of Enlicitide decanoate (HY-W1126955). Enlicitide northern fragment 4 participates in the protecting-group-free biocatalytic convergent assembly of Enlicitide decanoate, an oral macrocyclic peptide PCSK9 inhibitor. Enlicitide northern fragment 4 can be used for the synthesis of Enlicitide decanoate, thereby supporting research related to hypercholesterolemia.
For research use only. We do not sell to patients.
- CAS No.: 3115127-25-5
- Formula: C45H60FN7O16
- Molecular Weight:973.99
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
The northern fragment 4 of Enlicitide (50 mM; 32 h) undergoes a selective intermolecular transacylation reaction with Eastern fragment 3 catalyzed by engineered BITEEng, producing the coupled amino alcohol product with 89% LCAP and very low levels of by-products[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3115127-25-5
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Molecular Weight 973.99
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Formula C45H60FN7O16
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SMILES
OC(C(O)=O)=O.NCCCCCCN1C(C(C(C[C@H]2C([N@]3[C@@H]([C@](OCC(NCC4=CC=CC(C[C@@H](C(N2)=O)N)=C4)=O)([H])CC3)C(N[C@@H]([C@H](O)C)C(OC(C)C)=O)=O)=O)=C1)=C5)=CC=C5F.OC(C(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Enlicitide northern fragment 4 Related Classifications
HY-P12216 Related Classifications
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Keywords
- Enlicitide northern fragment 4
- 3115127-25-5
- Enlicitide northern fragment4
- Enlicitide northern fragment-4
- Drug Intermediate
- macrocyclic tetrapeptide
- macrocyclic peptide
- transacylation
- biocatalytic cascade
- macrocyclic bicyclic diamine
- synthetic intermediate
- amino alcohol product
- 5-enzyme one-pot sequential cascade
- BlTEEng
- Inhibitor
- inhibitor
- inhibit