PPNDS tetrasodium
Based on 1 Customer Validation
PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM). PPNDS tetrasodium is also a P2X1 receptor antagonist. PPNDS is an agonist for the ATP receptor of Paramecium. PPNDS tetrasodium potently inhibits polymerases from viruses. PPNDS tetrasodium can be used in the research of infection and cancers.
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- Pureza: 89.0%
- No. CAS: 1021868-77-8
- Fòrmula: C18H11N4Na4O14PS2
- Peso molecular:694.36
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Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Chemical Information
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Solvente y solubilidad
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Actividad biológica
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ADAM10 1.2 μM (IC50) |
p2x1 Receptor |
PPNDS tetrasodium inhibits meprin β (IC50: 80 nM) and meprin α (67 μM)[1].
PPNDS tetrasodium (0-10 μM, 15 min) inhibits mNV-RdRp (murine Norovirus RNA-dependent RNA-polymerase) with an IC50 value of 0.88 μM[2].
PPNDS tetrasodium (0.025-10 µM) potently inhibits polymerases from six viruses spanning the three Caliciviridae genera tested (IC50 range: 0.1-2.3 μM)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1021868-77-8
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Appearance Solid
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Peso molecular 694.36
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Fòrmula C18H11N4Na4O14PS2
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Color Brown to black
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SMILES
O=CC1=C(C(C)=NC(/N=N/C2=CC(S(=O)(O[Na])=O)=C(C=C([N+]([O-])=O)C=C3S(=O)(O[Na])=O)C3=C2)=C1COP(O[Na])(O[Na])=O)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
H2O : 37.5 mg/mL (54.01 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Franck Madoux, et al. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β. Biopolymers. 2014 Sep;102(5):396-406. [Content Brief]
[2]. Romina Croci, et al. PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases. FEBS Lett. 2014 May 2;588(9):1720-5. [Content Brief]
[3]. Christopher R Wood, et al. PPNDS is an agonist, not an antagonist, for the ATP receptor of Paramecium. J Exp Biol. 2003 Feb;206(Pt 3):627-36. [Content Brief]
[4]. Natalie E Netzler, et al. Broad-spectrum non-nucleoside inhibitors for caliciviruses. Antiviral Res. 2017 Oct;146:65-75. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.4402 mL | 7.2009 mL | 14.4018 mL | 36.0044 mL |
| 5 mM | 0.2880 mL | 1.4402 mL | 2.8804 mL | 7.2009 mL | |
| 10 mM | 0.1440 mL | 0.7201 mL | 1.4402 mL | 3.6004 mL | |
| 15 mM | 0.0960 mL | 0.4801 mL | 0.9601 mL | 2.4003 mL | |
| 20 mM | 0.0720 mL | 0.3600 mL | 0.7201 mL | 1.8002 mL | |
| 25 mM | 0.0576 mL | 0.2880 mL | 0.5761 mL | 1.4402 mL | |
| 30 mM | 0.0480 mL | 0.2400 mL | 0.4801 mL | 1.2001 mL | |
| 40 mM | 0.0360 mL | 0.1800 mL | 0.3600 mL | 0.9001 mL | |
| 50 mM | 0.0288 mL | 0.1440 mL | 0.2880 mL | 0.7201 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PPNDS tetrasodium Related Classifications
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