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Cat. No.: HY-W989128

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Ethyl 8-hydroxy-α-(2-propynylamino)

Ethyl 8-hydroxy-α-(2-propynylamino) is a bifunctional iron chelator that inhibits lipid peroxidation (IC₅₀ = 15 μM). Ethyl 8-hydroxy-α-(2-propynylamino) chelates Fe (II) and Fe (III) metal ions, and inhibits iron/ascorbic acid-induced mitochondrial membrane lipid peroxidation. Ethyl 8-hydroxy-α-(2-propynylamino) can be used in the research of oxidative stress and neurodegenerative diseases.

For research use only. We do not sell to patients.

CAS No.: 686723-15-9
Formula: C₁₇H₁₈N₂O₃
Molecular Weight:298.34

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Please store the product under the recommended conditions in the Certificate of Analysis.

Ethyl 8-hydroxy-α-(2-propynylamino) Chemical Structure

CAS No.: 686723-15-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

In Vitro

Ethyl 8-hydroxy-α-(2-propynylamino) (compound 11) exhibits moderate Fe²⁺ chelating activity in a cell-free fluorescent probe assay, with a half-maximal dequenching concentration [M]₁/₂ of 6.0 μM^[1].
Ethyl 8-hydroxy-α-(2-propynylamino) does not inhibit MAO-A or MAO-B activity in rat brain homogenates, with IC₅₀ values > 200 μM for both isoforms^[1].
Ethyl 8-hydroxy-α-(2-propynylamino) exhibits low permeability across the K562 cell membrane^[1].
Ethyl 8-hydroxy-α-(2-propynylamino) exhibits low lipophilicity in cell-free shake flask assays, with a log D value of 0.71^[1].
Ethyl 8-hydroxy-α-(2-propynylamino) inhibits Fe/ascorbic acid-induced lipid peroxidation in rat brain mitochondrial homogenate, with an IC₅₀ value of 15 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 686723-15-9
Molecular Weight 298.34
Formula C₁₇H₁₈N₂O₃
SMILES

O=C(OCC)C(NCC#C)CC=1C=CC(O)=C2N=CC=CC21
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zheng H, et al. Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases. Bioorganic & medicinal chemistry. 2005 Feb 01;13(3):773-83. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Ethyl 8-hydroxy-α-(2-propynylamino)

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Ethyl 8-hydroxy-α-(2-propynylamino)

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Chemical Information

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Calculators

Help & FAQs

Ethyl 8-hydroxy-α-(2-propynylamino) Related Classifications

HY-W989128 Related Classifications

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