Ethyl β-carboline-3-carboxylate
Based on 1 Customer Validation
Ethyl β-carboline-3-carboxylate (fl-CCE) is a ligand and short-acting antagonist of benzodiazepine receptors. Ethyl β-carboline-3-carboxylate did not affect cerebellar cGMP levels when used alone, but when taken together with Diazepam, it significantly inhibited the cGMP levels that were upregulated by Diazepam.
For research use only. We do not sell to patients.
- Purity: 99.75%
- CAS No.: 74214-62-3
- Formula: C14H12N2O2
- Molecular Weight:240.26
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Benzodiazepine receptor[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 769-P | IC50 |
175 μM
Compound: 4
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Cytotoxicity against human renal carcinoma 769-P cells assessed as reduction in optical density by MTT assay
Cytotoxicity against human renal carcinoma 769-P cells assessed as reduction in optical density by MTT assay
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[PMID: 23279863] |
| A-375 | IC50 |
>200 μM
Compound: 4
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Cytotoxicity against human malignant melanoma A375 cells assessed as reduction in optical density by MTT assay
Cytotoxicity against human malignant melanoma A375 cells assessed as reduction in optical density by MTT assay
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[PMID: 23279863] |
| A498 | IC50 |
>100 μM
Compound: 9
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Cytotoxicity against human A498 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human A498 cells incubated for 48 hrs by MTT assay
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[PMID: 26235951] |
| BGC-823 | IC50 |
>200 μM
Compound: 4
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Cytotoxicity against human gastric carcinoma BGC823 cells assessed as reduction in optical density by MTT assay
Cytotoxicity against human gastric carcinoma BGC823 cells assessed as reduction in optical density by MTT assay
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[PMID: 23279863] |
| COLO 205 | IC50 |
>100 μM
Compound: 9
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Cytotoxicity against human COLO205 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human COLO205 cells incubated for 48 hrs by MTT assay
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[PMID: 26235951] |
| Detroit 551 | IC50 |
>100 μM
Compound: 9
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Cytotoxicity against human Detroit 551 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human Detroit 551 cells incubated for 48 hrs by MTT assay
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[PMID: 26235951] |
| Hep 3B2 | IC50 |
>100 μM
Compound: 9
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Cytotoxicity against human Hep3B cells incubated for 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells incubated for 48 hrs by MTT assay
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[PMID: 26235951] |
| HL-60 | IC50 |
>100 μM
Compound: 9
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Cytotoxicity against human HL60 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HL60 cells incubated for 48 hrs by MTT assay
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[PMID: 26235951] |
| KB | IC50 |
>200 μM
Compound: 4
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Cytotoxicity against human epidermoid carcinoma of the nasopharynx KB cells assessed as reduction in optical density by MTT assay
Cytotoxicity against human epidermoid carcinoma of the nasopharynx KB cells assessed as reduction in optical density by MTT assay
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[PMID: 23279863] |
| NCI-H460 | IC50 |
>100 μM
Compound: 9
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Cytotoxicity against human H460 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human H460 cells incubated for 48 hrs by MTT assay
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[PMID: 26235951] |
| SK-OV-3 | IC50 |
>100 μM
Compound: 9
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Cytotoxicity against human SKOV3 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human SKOV3 cells incubated for 48 hrs by MTT assay
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[PMID: 26235951] |
| SK-OV-3 | IC50 |
92.6 μM
Compound: 4
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Cytotoxicity against human ovary adenocarcinoma SKOV3 cells assessed as reduction in optical density by MTT assay
Cytotoxicity against human ovary adenocarcinoma SKOV3 cells assessed as reduction in optical density by MTT assay
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[PMID: 23279863] |
Chemical Information
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CAS No. 74214-62-3
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Appearance Solid
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Molecular Weight 240.26
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Formula C14H12N2O2
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Color Off-white to light yellow
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SMILES
O=C(C1=CC2=C(C=N1)NC3=C2C=CC=C3)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (208.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1622 mL | 20.8108 mL | 41.6216 mL | 104.0539 mL |
| 5 mM | 0.8324 mL | 4.1622 mL | 8.3243 mL | 20.8108 mL | |
| 10 mM | 0.4162 mL | 2.0811 mL | 4.1622 mL | 10.4054 mL | |
| 15 mM | 0.2775 mL | 1.3874 mL | 2.7748 mL | 6.9369 mL | |
| 20 mM | 0.2081 mL | 1.0405 mL | 2.0811 mL | 5.2027 mL | |
| 25 mM | 0.1665 mL | 0.8324 mL | 1.6649 mL | 4.1622 mL | |
| 30 mM | 0.1387 mL | 0.6937 mL | 1.3874 mL | 3.4685 mL | |
| 40 mM | 0.1041 mL | 0.5203 mL | 1.0405 mL | 2.6013 mL | |
| 50 mM | 0.0832 mL | 0.4162 mL | 0.8324 mL | 2.0811 mL | |
| 60 mM | 0.0694 mL | 0.3468 mL | 0.6937 mL | 1.7342 mL | |
| 80 mM | 0.0520 mL | 0.2601 mL | 0.5203 mL | 1.3007 mL | |
| 100 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0405 mL |
Ethyl β-carboline-3-carboxylate Related Classifications
HY-137494 Related Classifications
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