Fmoc-Ala-Thr(psi(Me,Me)pro)-OH
Based on 1 Customer Validation
Fmoc-Ala-Thr (psi (Me,Me) pro)-OH is an Fmoc-protected pseudoproline derivative that serves as a building block for solid-phase peptide synthesis. Fmoc-Ala-Thr (psi (Me,Me) pro)-OH inhibits polypeptide aggregation and improves amino acid coupling efficiency during the synthesis of human and rat IAPP as well as general peptide synthesis. Fmoc-Ala-Thr (psi (Me,Me) pro)-OH is applicable to peptide synthesis-related research.
For research use only. We do not sell to patients.
- Purity : 99.49%
- CAS No.: 252554-79-3
- Formula: C25H28N2O6
- Molecular Weight:452.50
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Fmoc-Ala-Thr (psi (Me,Me) pro)-OH is a potent pseudoproline derivative that improves the solid-phase synthesis of human islet amyloid polypeptide and rat islet amyloid polypeptide by reducing aggregation and enhancing the coupling efficiency at positions 8 and 9 of the two peptides[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 252554-79-3
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Appearance Solid
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Molecular Weight 452.50
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Formula C25H28N2O6
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (220.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Valli D, et al. Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides. Biochemistry. 2025 Jun 17;64(12):2583-2595. [Content Brief]
[2]. Valli D, et al. Improving cryo-EM grids for amyloid fibrils using interface-active solutions and spectator proteins. Biophysical journal. 2024 Mar 19;123(6):718-729. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2099 mL | 11.0497 mL | 22.0994 mL | 55.2486 mL |
| 5 mM | 0.4420 mL | 2.2099 mL | 4.4199 mL | 11.0497 mL | |
| 10 mM | 0.2210 mL | 1.1050 mL | 2.2099 mL | 5.5249 mL | |
| 15 mM | 0.1473 mL | 0.7366 mL | 1.4733 mL | 3.6832 mL | |
| 20 mM | 0.1105 mL | 0.5525 mL | 1.1050 mL | 2.7624 mL | |
| 25 mM | 0.0884 mL | 0.4420 mL | 0.8840 mL | 2.2099 mL | |
| 30 mM | 0.0737 mL | 0.3683 mL | 0.7366 mL | 1.8416 mL | |
| 40 mM | 0.0552 mL | 0.2762 mL | 0.5525 mL | 1.3812 mL | |
| 50 mM | 0.0442 mL | 0.2210 mL | 0.4420 mL | 1.1050 mL | |
| 60 mM | 0.0368 mL | 0.1842 mL | 0.3683 mL | 0.9208 mL | |
| 80 mM | 0.0276 mL | 0.1381 mL | 0.2762 mL | 0.6906 mL | |
| 100 mM | 0.0221 mL | 0.1105 mL | 0.2210 mL | 0.5525 mL |
Fmoc-Ala-Thr(psi(Me,Me)pro)-OH Related Classifications
HY-P2392 Related Classifications
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