252554-79-3
Chemical Structure
Fmoc-Ala-Thr(psi(Me,Me)pro)-OH
- CAS No.: 252554-79-3
- Formula:C25H28N2O6
- Molecular Weight:452.50
IUPAC Name: (4S,5R)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)-L-alanyl)-2,2,5-trimethyloxazolidine-4-carboxylic acid
InChIKey: GBTYMCWKCJUKDT-ZSDSOXJFSA-N
SMILES: O=C([C@H]1N(C([C@@H](NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O)C)=O)C(C)(C)O[C@@H]1C)O
Biological Activity: Fmoc-Ala-Thr (psi (Me,Me) pro)-OH is an Fmoc-protected pseudoproline derivative that serves as a building block for solid-phase peptide synthesis. Fmoc-Ala-Thr (psi (Me,Me) pro)-OH inhibits polypeptide aggregation and improves amino acid coupling efficiency during the synthesis of human and rat IAPP as well as general peptide synthesis. Fmoc-Ala-Thr (psi (Me,Me) pro)-OH is applicable to peptide synthesis-related research[1][2].
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Fmoc-Ala-Thr(psi(Me,Me)pro)-OH | Fmoc-Ala-Thr (psi (Me,Me) pro)-OH is an Fmoc-protected pseudoproline derivative that serves as a building block for solid-phase peptide synthesis. Fmoc-Ala-Thr (psi (Me,Me) pro)-OH inhibits polypeptide aggregation and improves amino acid coupling efficiency during the synthesis of human and rat IAPP as well as general peptide synthesis. Fmoc-Ala-Thr (psi (Me,Me) pro)-OH is applicable to peptide synthesis-related research. | |||||||||||||||||||||
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- [1]. Valli D, et al. Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides. Biochemistry. 2025 Jun 17;64(12):2583-2595. [Content Brief]
- [2]. Valli D, et al. Improving cryo-EM grids for amyloid fibrils using interface-active solutions and spectator proteins. Biophysical journal. 2024 Mar 19;123(6):718-729. [Content Brief]
Keywords
