Fmoc-β-Ala-Trp(Boc)-OH

Cat. No.: HY-175994 Purity: 99.36%: Data Sheet
COA

SDS
Handling Instructions
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Fmoc-β-Ala-Trp(Boc)-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Fmoc-β-Ala-Trp(Boc)-OH Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

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Description

Fmoc-β-Ala-Trp(Boc)-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

In Vitro

Fmoc-β-Ala-Trp(Boc)-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

597.66

Formula

C₃₄H₃₅N₃O₇

Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C(O)=O)CC1=CN(C(OC(C)(C)C)=O)C2=CC=CC=C12)CCNC(OCC3C4=CC=CC=C4C5=CC=CC=C53)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (167.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6732 mL	8.3660 mL	16.7319 mL
5 mM	0.3346 mL	1.6732 mL	3.3464 mL
10 mM	0.1673 mL	0.8366 mL	1.6732 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.36%

Select Batch:

Data Sheet (246 KB) SDS (252 KB)

COA (255 KB) HNMR (469 KB) RP-HPLC (252 KB) MS (88 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6732 mL	8.3660 mL	16.7319 mL	41.8298 mL
	5 mM	0.3346 mL	1.6732 mL	3.3464 mL	8.3660 mL
	10 mM	0.1673 mL	0.8366 mL	1.6732 mL	4.1830 mL
	15 mM	0.1115 mL	0.5577 mL	1.1155 mL	2.7887 mL
	20 mM	0.0837 mL	0.4183 mL	0.8366 mL	2.0915 mL
	25 mM	0.0669 mL	0.3346 mL	0.6693 mL	1.6732 mL
	30 mM	0.0558 mL	0.2789 mL	0.5577 mL	1.3943 mL
	40 mM	0.0418 mL	0.2091 mL	0.4183 mL	1.0457 mL
	50 mM	0.0335 mL	0.1673 mL	0.3346 mL	0.8366 mL
	60 mM	0.0279 mL	0.1394 mL	0.2789 mL	0.6972 mL
	80 mM	0.0209 mL	0.1046 mL	0.2091 mL	0.5229 mL
	100 mM	0.0167 mL	0.0837 mL	0.1673 mL	0.4183 mL