4-Allylcatechol
Based on 1 publication(s) in Google Scholar
4-Allylcatechol (4-Allylpyrocatechol) is a xylan which has oral activity and can be isolated from the root of Piper taiwanense. 4-Allylcatechol has a strong inhibitory activity against collagen-induced platelet aggregation (IC50 = 5.3 μM). In addition, 4-Allylcatechol has anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv (MIC = 27.6 μg/mL).
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- Pureza : 98.60%
- No. CAS: 1126-61-0
- Fòrmula: C9H10O2
- Peso molecular:150.17
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) 4-Allylcatechol
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
83 μM
Compound: HC, Hydroxychavicol
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Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay
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[PMID: 24508612] |
| HepG2 | IC50 |
>30 μM
Compound: 1
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Growth inhibition of human HepG2 cells after 72 hrs by MTT assay
Growth inhibition of human HepG2 cells after 72 hrs by MTT assay
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[PMID: 25559204] |
| HL-60 | IC50 |
3 μM
Compound: 1
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Growth inhibition of human HL60 cells after 72 hrs by MTT assay
Growth inhibition of human HL60 cells after 72 hrs by MTT assay
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[PMID: 25559204] |
| HL-60 | IC50 |
50 μM
Compound: 1
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Growth inhibition of human HL60 cells after 24 hrs by MTT assay
Growth inhibition of human HL60 cells after 24 hrs by MTT assay
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[PMID: 25559204] |
| MCF7 | IC50 |
>30 μM
Compound: 1
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Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
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[PMID: 25559204] |
| MIA PaCa-2 | IC50 |
>30 μM
Compound: 1
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Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTT assay
Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTT assay
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[PMID: 25559204] |
| PC-3 | IC50 |
55 μM
Compound: HC, Hydroxychavicol
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Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay
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[PMID: 24508612] |
| RAW264.7 | IC50 |
4.8 μM
Compound: 6
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Anti-inflammatory activity in murine RAW264.7 cells assessed as inhibition of LPS-induced NO production
Anti-inflammatory activity in murine RAW264.7 cells assessed as inhibition of LPS-induced NO production
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[PMID: 33207281] |
| RBL-2H3 | IC50 |
>100 μM
Compound: 11
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Inhibitory activity against release of beta-hexosaminidase from RBL-2H3 cells
Inhibitory activity against release of beta-hexosaminidase from RBL-2H3 cells
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[PMID: 12951092] |
| SK-N-SH | IC50 |
>30 μM
Compound: 1
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Growth inhibition of human SK-N-SH cells after 72 hrs by MTT assay
Growth inhibition of human SK-N-SH cells after 72 hrs by MTT assay
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[PMID: 25559204] |
In Vitro
4-Allylcatechol (IC50 = 5.3 µM，MIC = 27.6 μg/mL) exhibits strong antiplatelet aggregation and antitubercular activity[1]. 4-Allylcatechol (IC50 = 99.83 µM) exhibits cytotoxicity in HT29 cells[2]. 4-Allylcatechol (100 μg/mL, 30 min) demonstrates potent antioxidant activity, with a radical scavenging rate of 77.05%[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT29 cells (Colon cancer)
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Concentration:62.5 μM to 1mM
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Incubation Time:24 hours
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Result:Showed an IC50 of 99.89 μM (15.0 µg/mL).
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Alzheimer’s disease (AD) model induced by Streptozotocin (HY-13753) in rats[4]
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Dosage:0.5, 1, 2, 4 mg/kg
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Administration:Oral gavage (p.o.), once daily for 21 days
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Result:Significantly improved cognitive function, decreased levels of TNF-α, IL-1β, IL-6, and reduced lipid peroxidation (MDA) in brain tissue.
Chemical Information
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No. CAS 1126-61-0
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Appearance Solid
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Peso molecular 150.17
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Fòrmula C9H10O2
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Color Light yellow to brown
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SMILES
OC1=CC=C(CC=C)C=C1O
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Synonyms
Hydroxychavicol; 4-Allylpyrocatechol
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Structure Classification
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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ACS Omega
Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer. [Abstract]2024 Feb 28;9(10):11870-11882. PMID: 38496939
Solvente y solubilidad
In Vitro:
DMSO : ≥ 100 mg/mL (665.91 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.65 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.65 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Chen S, et al. Neolignans and phenylpropanoids from the roots of Piper taiwanense and their antiplatelet and antitubercular activities[J]. Phytochemistry, 2013, 93: 203-209. [Content Brief]
[2]. Ng PL, et al. Piper betle leaf extract enhances the cytotoxicity effect of 5-fluorouracil in inhibiting the growth of HT29 and HCT116 colon cancer cells. J Zhejiang Univ Sci B. 2014 Aug;15(8):692-700. [Content Brief]
[4]. Pandey A, et al. Hydroxychavicol inhibits immune responses to mitigate cognitive dysfunction in rats. J Neuroimmunol. 2010 Sep 14;226(1-2):48-58. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.6591 mL | 33.2956 mL | 66.5912 mL | 166.4780 mL |
| 5 mM | 1.3318 mL | 6.6591 mL | 13.3182 mL | 33.2956 mL | |
| 10 mM | 0.6659 mL | 3.3296 mL | 6.6591 mL | 16.6478 mL | |
| 15 mM | 0.4439 mL | 2.2197 mL | 4.4394 mL | 11.0985 mL | |
| 20 mM | 0.3330 mL | 1.6648 mL | 3.3296 mL | 8.3239 mL | |
| 25 mM | 0.2664 mL | 1.3318 mL | 2.6636 mL | 6.6591 mL | |
| 30 mM | 0.2220 mL | 1.1099 mL | 2.2197 mL | 5.5493 mL | |
| 40 mM | 0.1665 mL | 0.8324 mL | 1.6648 mL | 4.1619 mL | |
| 50 mM | 0.1332 mL | 0.6659 mL | 1.3318 mL | 3.3296 mL | |
| 60 mM | 0.1110 mL | 0.5549 mL | 1.1099 mL | 2.7746 mL | |
| 80 mM | 0.0832 mL | 0.4162 mL | 0.8324 mL | 2.0810 mL | |
| 100 mM | 0.0666 mL | 0.3330 mL | 0.6659 mL | 1.6648 mL |
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