CDK9-IN-8
Based on 1 Customer Validation
CDK9-IN-8 is a highly effective and selective CDK9 inhibitor with an IC50 of 12 nM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.16%
- No. CAS: 2105956-51-0
- Fòrmula: C31H32FN7O3
- Peso molecular:569.63
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Kinase Inhibitor Library
HY-L009
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Anti-Cancer Compound Library
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Anti-Blood Cancer Compound Library
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Cancer Stem Cells Compound Library
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Heterocyclic Compound Library
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Highly Selective Inhibitors Library
HY-L158
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Serine/Threonine Kinase Inhibitor Library
HY-L164
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Anti-Hematopathy Compound Library
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Anti-Ovarian Cancer Compound Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Protein Kinase Compound Library
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High-Throughput Bioactive Compound Library
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Posttranslational Modification Library
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High-Efficiency Gene Editing Compound Library
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Actividad biológica
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CDK9 12 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
456 nM
Compound: 4d
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Growth inhibition of human A549 cells incubated for 72 hrs by CCK8 assay
Growth inhibition of human A549 cells incubated for 72 hrs by CCK8 assay
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[PMID: 28651979] |
| MCF7 | IC50 |
338 nM
Compound: 4d
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Growth inhibition of human MCF7 cells incubated for 72 hrs by CCK8 assay
Growth inhibition of human MCF7 cells incubated for 72 hrs by CCK8 assay
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[PMID: 28651979] |
| NCI-H1299 | IC50 |
221 nM
Compound: 4d
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Growth inhibition of human H1299 cells incubated for 72 hrs by CCK8 assay
Growth inhibition of human H1299 cells incubated for 72 hrs by CCK8 assay
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[PMID: 28651979] |
| NCI-H460 | IC50 |
359 nM
Compound: 4d
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Growth inhibition of human H460 cells incubated for 72 hrs by CCK8 assay
Growth inhibition of human H460 cells incubated for 72 hrs by CCK8 assay
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[PMID: 28651979] |
| T47D | IC50 |
358 nM
Compound: 4d
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Growth inhibition of human T47D cells incubated for 72 hrs by CCK8 assay
Growth inhibition of human T47D cells incubated for 72 hrs by CCK8 assay
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[PMID: 28651979] |
Chemical Information
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No. CAS 2105956-51-0
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Appearance Solid
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Peso molecular 569.63
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Fòrmula C31H32FN7O3
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Color Light yellow to yellow
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SMILES
FC1=CC=C(NC(C2(CC2)C(NC3=CC=C(NC4=NC=C5C(N(C6CCCC6)C(C(N(C)C)=O)=C5)=N4)C=C3)=O)=O)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
DMSO : 5.2 mg/mL (9.13 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7555 mL | 8.7776 mL | 17.5553 mL | 43.8881 mL |
| 5 mM | 0.3511 mL | 1.7555 mL | 3.5111 mL | 8.7776 mL |
CDK9-IN-8 Related Classifications
HY-102039 Related Classifications
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