Fleroxacin
Based on 1 publication(s) in Google Scholar
Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.90%
- No. CAS: 79660-72-3
- Fòrmula: C17H18F3N3O3
- Peso molecular:369.34
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Fleroxacin
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Actividad biológica
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Quinolone |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| V79 | IC50 |
>500 μg/mL
Compound: 5 Fleroxacin
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Mammalian cell cytotoxicity test in chinese hamster V79 cells (clonogenic cytotoxicity)
Mammalian cell cytotoxicity test in chinese hamster V79 cells (clonogenic cytotoxicity)
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[PMID: 1469702] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 79660-72-3
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Appearance Solid
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Peso molecular 369.34
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Fòrmula C17H18F3N3O3
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Color White to off-white
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SMILES
O=C(C1=CN(CCF)C2=C(C=C(F)C(N3CCN(C)CC3)=C2F)C1=O)O
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Synonyms
RO 23-6240; AM-833
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Biol Chem
Drug metabolism of ciprofloxacin, ivacaftor, and raloxifene by Pseudomonas aeruginosa cytochrome P450 CYP107S1. [Abstract]2024 Jul 18:107594. PMID: 39032655
Solvente y solubilidad
H2O : 33.33 mg/mL (90.24 mM; ultrasonic and adjust pH to 11 with NaOH)
0.1 M NaOH : 9.17 mg/mL (24.83 mM; ultrasonic and adjust pH to 12 with NaOH)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Weidekamm, E., et al., Single- and multiple-dose pharmacokinetics of fleroxacin, a trifluorinated quinolone, in humans. Antimicrob Agents Chemother, 1987. 31(12): p. 1909-14. [Content Brief]
[2]. MacDonald, K.S., et al., Evaluation of fleroxacin (RO 23-6240) as single-oral-dose therapy of culture-proven chancroid in Nairobi, Kenya. Antimicrob Agents Chemother, 1989. 33(5): p. 612-4. [Content Brief]
[3]. Rubinstein, E., History of quinolones and their side effects. Chemotherapy, 2001. 47 Suppl 3: p. 3-8; discussion 44-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 0.1 M NaOH / H2O | 1 mM | 2.7075 mL | 13.5377 mL | 27.0753 mL | 67.6883 mL |
| 5 mM | 0.5415 mL | 2.7075 mL | 5.4151 mL | 13.5377 mL | |
| 10 mM | 0.2708 mL | 1.3538 mL | 2.7075 mL | 6.7688 mL | |
| 15 mM | 0.1805 mL | 0.9025 mL | 1.8050 mL | 4.5126 mL | |
| 20 mM | 0.1354 mL | 0.6769 mL | 1.3538 mL | 3.3844 mL | |
| H2O | 25 mM | 0.1083 mL | 0.5415 mL | 1.0830 mL | 2.7075 mL |
| 30 mM | 0.0903 mL | 0.4513 mL | 0.9025 mL | 2.2563 mL | |
| 40 mM | 0.0677 mL | 0.3384 mL | 0.6769 mL | 1.6922 mL | |
| 50 mM | 0.0542 mL | 0.2708 mL | 0.5415 mL | 1.3538 mL | |
| 60 mM | 0.0451 mL | 0.2256 mL | 0.4513 mL | 1.1281 mL | |
| 80 mM | 0.0338 mL | 0.1692 mL | 0.3384 mL | 0.8461 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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