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United States

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Referencia número: HY-P991480

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Biologically Validated

ONC-841

Revisión del cliente

Based on 1 Customer Validation

ONC-841 is a blood-brain barrier-permeable, humanized monoclonal antibody targeting SIGLEC10. As an immune checkpoint inhibitor, ONC-841 restores the functions of immune effector cells such as T cells and enhances anti-tumor immune responses by blocking inhibitory signals mediated by SIGLEC10. ONC-841 restores the phagocytic and migratory activities of microglia, and promotes the phagocytosis of Amyloid-β and Tau protein aggregates by microglia. ONC-841 is applicable to research related to solid tumors and Alzheimer's disease.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 95.03%
Peso molecular:145.08 kDa

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

ONC-841 Chemical Structure

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Aplicación
- Verified Bioactivity
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Isotype

Human IgG4 kappa

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

Siglec-10

In Vitro

ONC-841 promotes phagocytosis of amyloid-β and Tau aggregates by IPS-derived human microglia and mouse primary microglia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The mouse IgG isotype clone (31F11) of ONC-841 (intravenous injection; 6.5 weeks) clears cerebral β-amyloid plaques, reduces plasma pTau181 and total Tau biomarker levels, and restores microglial function, thereby counteracting AD pathogenesis in two Alzheimer's disease transgenic mouse models expressing human SIGLEC10^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

89790 [NCBI]

Accession

Q96LC7

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Aplicación

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Siglec-10-hFc can bind ONC-841. The EC₅₀ for this effect is 34.77 ng/mL.

Chemical Information

Appearance Liquid
Peso molecular 145.08 kDa
Color Colorless to light yellow
SMILES

[ONC-841]
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (258 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. Wang P, et al. Therapeutic activities of anti‐human SIGLEC10 mAb in Multiple Transgenic Mouse AD Models. Alzheimer's & Dementia. 2025 Dec;21:e101818.

[2]. Sobczak K, et al. The unique molecular recognition features of Siglec-10: structural insights into sialoglycan and antibody interactions. bioRxiv. 2025 Jun 10:2025-06.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Aplicación
- Biological Activity
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

ONC-841

DPBS Buffer (1×)

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

ONC-841 Related Classifications

HY-P991480 Related Classifications