SIGLEC10 - sialic acid binding Ig like lectin 10 Gene

Also Known as SLG2; PRO940; SIGLEC-10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 89790

About SIGLEC10

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,410,020-51,417,642 (from NCBI)

This gene has 11 transcripts (splice variants), 124 orthologues and 16 paralogues. Biased expression in appendix (RPKM 14.2), spleen (RPKM 13.0) and 12 other tissues.

Summary

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

SIGLEC10 Products (7)

mRNA Protein Name
NM_001171156.2 NP_001164627.1 sialic acid-binding Ig-like lectin 10 isoform 2 precursor
NM_001171157.2 NP_001164628.1 sialic acid-binding Ig-like lectin 10 isoform 3 precursor
NM_001171158.2 NP_001164629.1 sialic acid-binding Ig-like lectin 10 isoform 4 precursor
NM_001171159.2 NP_001164630.1 sialic acid-binding Ig-like lectin 10 isoform 5 precursor
NM_001171161.2 NP_001164632.1 sialic acid-binding Ig-like lectin 10 isoform 7 precursor
NM_001322105.2 NP_001309034.1 sialic acid-binding Ig-like lectin 10 isoform 8 precursor
NM_033130.5 NP_149121.2 sialic acid-binding Ig-like lectin 10 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables SH2 domain binding IMP
IMP: Inferred from mutant phenotype
12163025 GOA
enables phosphatase binding IPI
IPI: Inferred from physical interaction
12163025 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19264983 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of inflammatory response to wounding IPI
IPI: Inferred from physical interaction
19264983 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11284738 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGLEC10 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (26 - 129)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (147 - 223)

I-set

I-set: Immunoglobulin I-set domain (264 - 340)

Ig_2

Ig_2: Immunoglobulin domain (369 - 442)

  • 0
  • 200
  • 400
  • 600
  • 697 a.a.
Protein Preferred Names Protein Names

sialic acid-binding Ig-like lectin 10

  • sialic acid binding Ig-like lectin 10 Ig-like lectin 7

Recombinant SIGLEC10 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P72411 Siglec-10 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q96LC7-1 (M17-T546) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72476 Siglec-10 Protein, Human (HEK293, Fc) Q96LC7-1 (M17-T546) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76642 Siglec-10 Protein, Human (HEK293, His) AAI01726.1 (M17-N550) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78205 Siglec-10 Protein, Human (Biotinylated, HEK293, His-Avi) Q96LC7-1 (M17-T546) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78206 Siglec-10 Protein, Human (Biotinylated, R119A, HEK293, His-Avi) Q96LC7-1 (M17-T546, R119A) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78514 Siglec-10 Protein, Human (R119A, HEK293, His-Avi) Q96LC7-1 (M17-T546, R119A) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78516 Siglec-10 Protein, Human (HEK293, Fc-Avi) Q96LC7-1 (M17-T546) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P10091 CD24/Siglec-10 blocking peptide, CSBP Inhibitor 99.12% Unkown
HY-RS12898 SIGLEC10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26351 Siglec10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P991480 ONC-841 Inhibitor 95.03% Unkown
HY-P99928 Efprezimod alfa 99.25% Unkown
HY-P992303 Anti-Siglec-10/CD24 Antibody / Unkown
HY-P992441 PHST001 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SIGLEC10 VGNC VGNC:77237
Rattus norvegicus SIGLEC10 RGD RGD:1307441
Mus musculus SIGLEC10 MGD MGI:2443630
Others SIGLEC10 NCBI