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Referencia número: HY-21302

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SGM8

SGM8 is a selective HCMV UL44 inhibitor, with an IC₅₀ of 4.5 μM for the interaction between HCMV UL44 and full-length HCMV UL54. SGM8 selectively inhibits UL44-dependent long-strand DNA synthesis, while exerting weak inhibitory effects on UL54-only dependent short-strand DNA synthesis. SGM8 can be used in studies related to cytomegalovirus infection.

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No. CAS: 882268-09-9
Fòrmula: C₁₂H₁₅NOS₂
Peso molecular:253.38

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Please store the product under the recommended conditions in the Certificate of Analysis.

SGM8 Chemical Structure

No. CAS: 882268-09-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas DNA/RNA Synthesis :

In Vitro

SGM8 (0.1-100 μM; 10-60 min) time-dependently inhibits the interaction of HCMV UL44 with the UL54-derived P54 peptide, with an IC₅₀ of 2 μM following 20 min or longer of pre-incubation^[1].
SGM8 (0.1-100 μM) inhibits the interaction of HCMV UL44 with full-length HCMV UL54 with an IC₅₀ of 4.5 μM^[1].
SGM8 (0.1-100 μM) selectively inhibits UL44-dependent long-chain DNA synthesis by HCMV UL54 with an IC₅₀ of 3.2 μM, while showing minimal inhibition of short-chain DNA synthesis by UL54 alone (IC₅₀ > 100 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 882268-09-9
Peso molecular 253.38
Fòrmula C₁₂H₁₅NOS₂
SMILES

O=C1C2=C(SC=C2CCC1=CN(C)C)SC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Chen H, et al. A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions. ACS infectious diseases. 2017 Feb 10;3(2):112-118.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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SGM8

Ver todos los productos específicos de isoformas DNA/RNA Synthesis