2. Anti-infection
  3. SARS-CoV Virus Protease
  4. GCLE

GCLE  (Synonyms: Cephalosporin G 3-chloromethyl p-methoxybenzyl ester)

Cat. No.: HY-W018563
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GCLE (Cephalosporin G 3-chloromethyl p-methoxybenzyl ester) is a SARS-CoV-2 main protease (Mpro) inhibitor with an IC50 of 0.03 μM. GCLE selectively acylates the Cys145 residue of Mpro. GCLE is applicable to research related to COVID-19.

For research use only. We do not sell to patients.

GCLE

GCLE Chemical Structure

CAS No. : 104146-10-3

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GCLE Related Antibodies

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Description

GCLE (Cephalosporin G 3-chloromethyl p-methoxybenzyl ester) is a SARS-CoV-2 main protease (Mpro) inhibitor with an IC50 of 0.03 μM. GCLE selectively acylates the Cys145 residue of Mpro. GCLE is applicable to research related to COVID-19[1].

In Vitro

GCLE (5-20 μM) modestly reduces SARS-CoV-2 replication in infected VeroE6 cells at 20 μM, though it shows no activity at 5 μM and exhibits cytotoxicity at active concentrations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GCLE Related Antibodies
Molecular Weight

486.97

Formula

C24H23ClN2O5S
CAS No.
Appearance

Solid

SMILES

O=C(N[C@@H]1C(N2C(C(OCC3=CC=C(OC)C=C3)=O)=C(CS[C@H]12)CCl)=O)CC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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GCLE Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GCLE104146-10-3Cephalosporin G 3-chloromethyl p-methoxybenzyl esterSARS-CoVVirus ProteaseSARS coronavirusMproSARS-CoV-2 main proteaseVeroE6 cellsCys145covid-19Inhibitorinhibitorinhibit

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