Egr2 - early growth response 2 Gene

Also Known as Krox20

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114090

Summary

Enables HMG box domain binding activity. Involved in learning or memory; regulation of neuronal synaptic plasticity; and response to Insulin. Predicted to be located in cytoplasm and nucleoplasm. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2). [provided by Alliance of Genome Resources, Apr 2022]

Egr2 Products (1)

mRNA Protein Name
NM_053633.2 NP_446085.1 E3 SUMO-protein ligase EGR2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables HMG box domain binding IPI
IPI: Inferred from physical interaction
16582099 RGD
Biological Process GO Annotation Evidence References Source
involved in learning or memory IEP
IEP: Inferred from expression pattern
8619872 RGD
involved in regulation of neuronal synaptic plasticity IEP
IEP: Inferred from expression pattern
8619872 RGD
involved in response to insulin IMP
IMP: Inferred from mutant phenotype
12970165 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 SUMO-protein ligase EGR2

  • E3 SUMO-protein transferase ERG2

  • EGR-2

  • early growth response protein 2

  • zinc finger protein Krox-20

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04216 EGR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19327 Egr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25818 Egr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Egr2 NCBI NCBI:1959