Adam19 - a disintegrin and metallopeptidase domain 19 (meltrin beta) Gene

Also Known as MTLNB; Mltnb; MADDAM

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11492

Summary

This gene encodes a cell surface glycoprotein and member of the ADAM (a disintegrin and metalloproteinase) family of endopeptidases. The encoded protein may play a role in the ectodomain shedding of neuregulin proteins. Homozygous knockout mice for this gene exhibit heart development defects and perinatal lethality. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that undergoes proteolytic processing to generate a mature protein product. [provided by RefSeq, Aug 2015]

Adam19 Products (4)

mRNA Protein Name
NM_001291890.1 NP_001278819.1 disintegrin and metalloproteinase domain-containing protein 19 isoform 2
NM_001291891.1 NP_001278820.1 disintegrin and metalloproteinase domain-containing protein 19 isoform 3
NM_001311209.1 NP_001298138.1 disintegrin and metalloproteinase domain-containing protein 19 isoform 4
NM_009616.4 NP_033746.1 disintegrin and metalloproteinase domain-containing protein 19 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH3 domain binding IMP
IMP: Inferred from mutant phenotype
12615925 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10527948 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
14673146 MGI
acts upstream of or within membrane protein ectodomain proteolysis IDA
IDA: Inferred from direct assay
11116142 MGI
acts upstream of or within membrane protein ectodomain proteolysis IMP
IMP: Inferred from mutant phenotype
11116142 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
11116142 MGI
NOT located in external side of plasma membrane IDA
IDA: Inferred from direct assay
11116142 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 19

  • MDC beta

  • Mel beta

  • a disintegrin and metalloproteinase domain 19 (meltrin beta)

  • adamalysin 19

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00275 ADAM19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18194 Adam19 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24668 Adam19 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adam19 NCBI NCBI:8728