Alas2 - aminolevulinic acid synthase 2, erythroid Gene

Also Known as ALAS; ALASE; ALAS-E; Alas-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11656

Summary

Enables 5-aminolevulinate synthase activity. Involved in erythrocyte differentiation; heme biosynthetic process; and Hemoglobin biosynthetic process. Acts upstream of or within cellular iron ion homeostasis. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in cutaneous porphyria; erythropoietic protoporphyria; hemochromatosis; sideroblastic anemia; and sideroblastic anemia 1. Orthologous to human ALAS2 (5'-aminolevulinate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

Alas2 Products (8)

mRNA Protein Name
NM_001102446.2 NP_001095916.1 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform b
NM_001409472.1 NP_001396401.1 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform c
NM_001409473.1 NP_001396402.1 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform d
NM_001409474.1 NP_001396403.1 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform e
NM_001409475.1 NP_001396404.1 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform f
NM_001409476.1 NP_001396405.1 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform g
NM_001409477.1 NP_001396406.1 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform h
NM_009653.4 NP_033783.1 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5-aminolevulinate synthase activity IDA
IDA: Inferred from direct assay
3557128 MGI
enables 5-aminolevulinate synthase activity IMP
IMP: Inferred from mutant phenotype
7620186 MGI
Biological Process GO Annotation Evidence References Source
involved in erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
9446639 MGI
involved in heme biosynthetic process IMP
IMP: Inferred from mutant phenotype
9446639 MGI
involved in hemoglobin biosynthetic process IMP
IMP: Inferred from mutant phenotype
9446639 MGI
acts upstream of or within intracellular iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
10562540 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
3557128 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5-aminolevulinate synthase, erythroid-specific, mitochondrial

  • 5-aminolevulinic acid synthase 2

  • delta-ALA synthase 2

  • delta-aminolevulinate synthase 2

  • erythroid-specific ALAS

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00555 ALAS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19407 Alas2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25899 Alas2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alas2 NCBI NCBI:212