Col4a4 - collagen, type IV, alpha 4 Gene

Also Known as [a]4(IV); E130010M05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12829

Summary

An extracellular matrix structural constituent. Acts upstream of or within glomerular basement membrane development. Located in basement membrane. Part of Collagen type IV trimer. Is expressed in glomerular tuft and testis. Used to study autosomal recessive Alport syndrome. Human ortholog(s) of this gene implicated in autosomal recessive Alport syndrome; benign familial hematuria; and end stage renal disease. Orthologous to human COL4A4 (Collagen type IV alpha 4 chain). [provided by Alliance of Genome Resources, Apr 2022]

Col4a4 Products (1)

mRNA Protein Name
NM_007735.2 NP_031761.1 collagen alpha-4(IV) chain precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables extracellular matrix structural constituent IPI
IPI: Inferred from physical interaction
7962065 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within glomerular basement membrane development IMP
IMP: Inferred from mutant phenotype
10534397 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
9264260 MGI
part of collagen type IV trimer IDA
IDA: Inferred from direct assay
7962065 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-4(IV) chain

  • procollagen, type IV, alpha 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02986 COL4A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18857 Col4a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25349 Col4a4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col4a4 NCBI NCBI:1286