METTL6 - methyltransferase 6, methylcytidine Gene

Also Known as hMETTL6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 131965

About METTL6

Cytogenetic location: 3p25.1 Genomic coordinates (GRCh38): 3:15,381,275-15,427,643 (from NCBI)

This gene has 10 transcripts (splice variants), 201 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 1.5), brain (RPKM 1.4) and 25 other tissues.

Summary

Enables enzyme binding activity. Involved in tRNA methylation. [provided by Alliance of Genome Resources, Apr 2022]

METTL6 Products (5)

mRNA Protein Name
NM_001301790.2 NP_001288719.1 tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 2
NM_001301791.2 NP_001288720.1 tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 3
NM_001301792.2 NP_001288721.1 tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 4
NM_001330662.2 NP_001317591.1 tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 5
NM_152396.4 NP_689609.2 tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
28655767 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables tRNA (cytidine-3-)-methyltransferase activity IDA
IDA: Inferred from direct assay
32923617 GOA
Biological Process GO Annotation Evidence References Source
involved in tRNA methylation IDA
IDA: Inferred from direct assay
32923617 GOA
involved in tRNA modification IDA
IDA: Inferred from direct assay
34268557 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
34268557 GOA
located in nucleus IDA
IDA: Inferred from direct assay
34268557 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL6 Protein Structure

Methyltransf_12

Methyltransf_12: Methyltransferase domain (84 - 182)

  • 0
  • 100
  • 200
  • 284 a.a.
Protein Preferred Names Protein Names

tRNA N(3)-methylcytidine methyltransferase METTL6

  • methyltransferase like 6

Related Diseases

Diseases Alias
Adult Hepatocellular Carcinoma

  • Adult Primary Hepatocellular Carcinoma

  • Adult Hepatoma

  • Adult Hcc
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08367 METTL6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus METTL6 RGD RGD:1359565
Felis catus METTL6 VGNC VGNC:63467
Mus musculus METTL6 MGD MGI:1914261
Bos taurus METTL6 VGNC VGNC:31415
Macaca mulatta METTL6 VGNC VGNC:74601