METTL6 - methyltransferase 6, methylcytidine Gene

Homo sapiens

Also known as hMETTL6

Gene ID: 131965 | Gene type: protein coding

About METTL6

Cytogenetic location: 3p25.1 Genomic coordinates (GRCh38): 3:15,381,275-15,427,643 (from NCBI)

This gene has 10 transcripts (splice variants), 201 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 1.5), brain (RPKM 1.4) and 25 other tissues.

Summary

Enables Enzyme binding activity. Involved in tRNA methylation. [provided by Alliance of Genome Resources, Apr 2022]

METTL6 Products(5)

mRNA	Protein	Name
NM_001301790.2	NP_001288719.1	tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 2
NM_001301791.2	NP_001288720.1	tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 3
NM_001301792.2	NP_001288721.1	tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 4
NM_001330662.2	NP_001317591.1	tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 5
NM_152396.4	NP_689609.2	tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 1

METTL6 Protein Structure

Methyltransf_12

0
100
200
284 a.a.

Protein Preferred Names

Protein Names

tRNA N(3)-methylcytidine methyltransferase METTL6

methyltransferase like 6

Related Diseases

Diseases

Alias

Adult Hepatocellular Carcinoma

Adult Primary Hepatocellular Carcinoma	Adult Hepatoma
Adult Hcc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08367	METTL6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	METTL6	RGD	RGD:1359565
Felis catus	METTL6	VGNC	VGNC:63467
Mus musculus	METTL6	MGD	MGI:1914261
Bos taurus	METTL6	VGNC	VGNC:31415
Macaca mulatta	METTL6	VGNC	VGNC:74601

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