Egr2 - early growth response 2 Gene

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SUMO Ligase activity. Involved in several processes, including nervous system development; positive regulation of myelination; and protein sumoylation. Acts upstream of or within several processes, including nervous system development; regulation of ossification; and skeletal muscle cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; head mesenchyme derived from neural crest; nervous system; neural ectoderm; and vibrissa. Used to study Charcot-Marie-Tooth disease type 4E. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2). [provided by Alliance of Genome Resources, Apr 2022]