Kcnj8 - potassium inwardly-rectifying channel, subfamily J, member 8 Gene

Also Known as sltr; gnite; slmbr; Kir6.1; uKATP-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16523

Summary

Predicted to enable several functions, including ATP binding activity; sulfonylurea receptor binding activity; and voltage-gated Potassium Channel activity. Acts upstream of or within several processes, including defense response to virus; response to exogenous dsRNA; and response to lipopolysaccharide. Located in myofibril. Is expressed in genitourinary system and heart. Used to study coronary artery disease and hypertrichotic osteochondrodysplasia Cantu type. Orthologous to human KCNJ8 (potassium inwardly rectifying channel subfamily J member 8). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj8 Products (6)

mRNA Protein Name
NM_001330363.1 NP_001317292.1 ATP-sensitive inward rectifier potassium channel 8 isoform 1
NM_001330366.1 NP_001317295.1 ATP-sensitive inward rectifier potassium channel 8 isoform 2
NM_008428.5 NP_032454.1 ATP-sensitive inward rectifier potassium channel 8 isoform 1
NM_001330363.1 NP_001317292.1 ATP-sensitive inward rectifier potassium channel 8 isoform 1
NM_001330366.1 NP_001317295.1 ATP-sensitive inward rectifier potassium channel 8 isoform 2
NM_008428.5 NP_032454.1 ATP-sensitive inward rectifier potassium channel 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18001767 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within CAMKK-AMPK signaling cascade IMP
IMP: Inferred from mutant phenotype
24498880 MGI
acts upstream of or within NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
28928055 MGI
acts upstream of or within NLRP3 inflammasome complex assembly IMP
IMP: Inferred from mutant phenotype
28928055 MGI
acts upstream of or within action potential IGI
IGI: Inferred from genetic interaction
16501027 MGI
acts upstream of or within action potential IMP
IMP: Inferred from mutant phenotype
21984445 MGI
acts upstream of or within adaptive immune response IMP
IMP: Inferred from mutant phenotype
17077304 MGI
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
24498880 MGI
acts upstream of or within atrioventricular node cell differentiation IMP
IMP: Inferred from mutant phenotype
29666184 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
30089727 MGI
acts upstream of or within calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
28893911 MGI
acts upstream of or within cardiac pacemaker cell differentiation IMP
IMP: Inferred from mutant phenotype
29666184 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
28928055 MGI
acts upstream of or within circulatory system development IMP
IMP: Inferred from mutant phenotype
30089727 MGI
acts upstream of or within coronary vasculature development IGI
IGI: Inferred from genetic interaction
31821173 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
11984590 MGI
acts upstream of or within cytokine production IGI
IGI: Inferred from genetic interaction
19166858 MGI
acts upstream of or within defense response to virus IMP
IMP: Inferred from mutant phenotype
18026101 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: Inferred from genetic interaction
16501027 MGI
acts upstream of or within endothelin production IMP
IMP: Inferred from mutant phenotype
17341678 MGI
acts upstream of or within establishment of cell polarity IDA
IDA: Inferred from direct assay
29540778 MGI
acts upstream of or within establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
29540778 MGI
acts upstream of or within fat cell differentiation IMP
IMP: Inferred from mutant phenotype
26828268 MGI
acts upstream of or within fatty acid transport IMP
IMP: Inferred from mutant phenotype
26828268 MGI
acts upstream of or within fibroblast proliferation IGI
IGI: Inferred from genetic interaction
19166858 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
26828268 MGI
acts upstream of or within glutamate secretion, neurotransmission IGI
IGI: Inferred from genetic interaction
17883401 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
18026101 MGI
acts upstream of or within heart morphogenesis IGI
IGI: Inferred from genetic interaction
31821173 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
30089727 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
29540778 MGI
acts upstream of or within microglial cell activation IMP
IMP: Inferred from mutant phenotype
29540778 MGI
acts upstream of or within nervous system process IMP
IMP: Inferred from mutant phenotype
30315808 MGI
acts upstream of or within neuromuscular process IMP
IMP: Inferred from mutant phenotype
17883401 MGI
acts upstream of or within p38MAPK cascade IMP
IMP: Inferred from mutant phenotype
29540778 MGI
acts upstream of or within phloem or xylem histogenesis IMP
IMP: Inferred from mutant phenotype
24914196 MGI
acts upstream of or within potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
28928055 MGI
acts upstream of or within protein secretion IMP
IMP: Inferred from mutant phenotype
26828268 MGI
acts upstream of or within reactive gliosis IMP
IMP: Inferred from mutant phenotype
30315808 MGI
acts upstream of or within regulation of blood pressure IGI
IGI: Inferred from genetic interaction
31821173 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
24914196 MGI
acts upstream of or within regulation of cation channel activity IGI
IGI: Inferred from genetic interaction
31821173 MGI
acts upstream of or within regulation of heart rate IMP
IMP: Inferred from mutant phenotype
29666184 MGI
acts upstream of or within response to ATP IMP
IMP: Inferred from mutant phenotype
21984445 MGI
acts upstream of or within response to cytokine IMP
IMP: Inferred from mutant phenotype
17077304 MGI
acts upstream of or within response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
30315808 MGI
acts upstream of or within response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
18026101 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
28893911 MGI
acts upstream of or within response to insulin IMP
IMP: Inferred from mutant phenotype
28928055 MGI
acts upstream of or within response to ischemia IMP
IMP: Inferred from mutant phenotype
21984445 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
17077304 MGI
acts upstream of or within response to resveratrol IMP
IMP: Inferred from mutant phenotype
24498880 MGI
acts upstream of or within response to stress IGI
IGI: Inferred from genetic interaction
16501027 MGI
acts upstream of or within response to xenobiotic stimulus IGI
IGI: Inferred from genetic interaction
31821173 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
11984590 MGI
acts upstream of or within synaptic assembly at neuromuscular junction IMP
IMP: Inferred from mutant phenotype
26142302 MGI
acts upstream of or within transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
26142302 MGI
acts upstream of or within vasculature development IMP
IMP: Inferred from mutant phenotype
11984590 MGI
acts upstream of or within vasodilation IMP
IMP: Inferred from mutant phenotype
11984590 MGI
acts upstream of or within ventricular cardiac muscle tissue development IGI
IGI: Inferred from genetic interaction
16501027 MGI
Cellular Component GO Annotation Evidence References Source
located in myofibril IDA
IDA: Inferred from direct assay
16085792 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
17883401 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
17883401 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-sensitive inward rectifier potassium channel 8

  • inward rectifier K(+) channel Kir6.1

  • inwardly rectifier K(+) channel Kir6.1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07150 KCNJ8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22588 Kcnj8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnj8 NCBI NCBI:3764