EEF1A1 - eukaryotic translation elongation factor 1 alpha 1 Gene

Also Known as CCS3; EF1A; PTI1; CCS-3; EE1A1; EEF-1; EEF1A; EF-Tu; EF1A1; LENG7; eEF1A-1; GRAF-1EF; EF1alpha1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1915

About EEF1A1

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:73,515,750-73,521,032 (from NCBI)

This gene has 23 transcripts (splice variants), 236 orthologues and 18 paralogues. Ubiquitous expression in ovary (RPKM 2994.9), thyroid (RPKM 2551.7) and 25 other tissues.

Summary

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the Other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]

EEF1A1 Products (1)

mRNA	Protein	Name
NM_001402.6	NP_001393.1	elongation factor 1-alpha 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	26593721	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	18263879	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	26651998	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9852145	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17177976	GOA
enables tRNA binding	IDA IDA: Inferred from direct assay	12426392	GOA
enables translation elongation factor activity	IDA IDA: Inferred from direct assay	26593721	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	9852145	GOA
involved in positive regulation by host of viral genome replication	IDA IDA: Inferred from direct assay	33495306	GOA
involved in translational elongation	IDA IDA: Inferred from direct assay	26593721	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	19158340	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	8743958	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19158340	GOA
is active in cytosolic ribosome	IDA IDA: Inferred from direct assay	36638793	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	9852145	GOA
NOT located in nucleus	IDA IDA: Inferred from direct assay	12426392	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8743958	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	26497934	GOA
is active in ribosome	IDA IDA: Inferred from direct assay	26651998	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	19158340	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EEF1A1 Protein Structure

GTP_EFTU

GTP_EFTU_D2

GTP_EFTU_D3

0
100
200
300
400
462 a.a.

Protein Preferred Names	Protein Names
elongation factor 1-alpha 1	CTCL tumor antigen

EEF1A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EEF1A1	P68104	NLGN3	Homo sapiens	Q9NZ94-2	Confocal	25464930
Intra	EEF1A1	P68104	NLGN3	Homo sapiens	Q9NZ94-2	Anti Tag CoIP	25464930
Intra	EEF1A1	P68104	NLGN3	Homo sapiens	Q9NZ94-2	Y2H	25464930
Intra	EEF1A1	P68104	BBS1	Homo sapiens	Q8NFJ9	Y2H	18000879
Intra	EEF1A1	P68104	BOD1	Homo sapiens	Q96IK1-2	Validated Y2H	32814053
Intra	EEF1A1	P68104	BOD1	Homo sapiens	Q96IK1-2	Y2H Array	32814053
Intra	EEF1A1	P68104	BOD1	Homo sapiens	Q96IK1-2	Y2H Pooling	32814053
Intra	EEF1A1	P68104	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	EEF1A1	P68104	PCNA	Homo sapiens	P12004	BiFC	26030842
Intra	EEF1A1	P68104	PCNA	Homo sapiens	P12004	Far-WB	20849852
Intra	EEF1A1	P68104	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	17373842
Intra	EEF1A1	P68104	MDM2	Homo sapiens	Q00987	Pull Down	23260144
Intra	EEF1A1	P68104	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
Intra	EEF1A1	P68104	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
Intra	EEF1A1	P68104	MAPK14	Homo sapiens	Q16539	Y2H	18624398
Intra	EEF1A1	P68104	TTLL12	Homo sapiens	Q14166	Anti Tag CoIP	28514442
Intra	EEF1A1	P68104	TTLL12	Homo sapiens	Q14166	Validated Y2H	32296183
Intra	EEF1A1	P68104	TTLL12	Homo sapiens	Q14166	Anti Tag CoIP	33961781
Intra	EEF1A1	P68104	SPHK1	Homo sapiens	Q9NYA1	Anti Tag CoIP	20838377

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EEF1A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72178	EEF1A1 Protein, Human (His-SUMO)	P68104 (M1-K462)	≥ 90%, as determined by reducing SDS-PAGE.

EEF1A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80654	Elongation Factor 1A1 Antibody (YA460)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P80654A	Elongation Factor 1A1 Antibody (YA460)(PBS only)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Felty Syndrome	Felty'S Syndrome Rheumatoid Arthritis With Splenoadenomegaly And Leukopenia Familial Felty'S Syndrome Rheumatoid Arthritis, Splenomegaly And Neutropenia Splenomegaly-Neutropenia-Rheumatoid Arthritis Syndrome Feltys Syndrome
Eukaryotic Translation Elongation Factor 1 Alpha-1-Like 14	EEF1A1L14 Prostatic Carcinoma Tumor-Inducing Gene 1 Pti1
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome	ACOGS
Legionnaire Disease	Legionnaires' Disease Legionnaires Disease Legionnaire Disease, Susceptibility To Legionella Legionella Pneumonia Infection By Legionella Pneumophilia Legionnaire'S Disease Legionellosis Legionaire Disease, Susceptibility To Legionnaires Pneumonia
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Legionellosis	Legionella Infection Pontiac Fever Legionnaires' Disease Infection By Legionella Pneumophilia Legionella Pneumophila Infection
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123035	Gamendazole	Inhibitor	99.44%	Unkown
HY-RS04174	EEF1A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04178	EEF1E1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18307	Eef1a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24785	Eef1a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EEF1A1	MGD	MGI:1096881
Rattus norvegicus	EEF1A1	RGD	RGD:67387
Macaca mulatta	EEF1A1	VGNC	VGNC:81065
Bos taurus	EEF1A1	VGNC	VGNC:56362
Others	EEF1A1	NCBI