Akr1d1 - aldo-keto reductase family 1, member D1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 192242

Summary

Enables 3-oxo-5-beta-steroid 4-dehydrogenase activity. Predicted to be involved in cellular hormone metabolic process; Cholesterol catabolic process; and digestion. Predicted to act upstream of or within bile acid biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 2. Orthologous to human AKR1D1 (aldo-keto reductase family 1 member D1). [provided by Alliance of Genome Resources, Apr 2022]

Akr1d1 Products (1)

mRNA Protein Name
NM_138884.2 NP_620239.2 aldo-keto reductase family 1 member D1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables 3-oxo-5-beta-steroid 4-dehydrogenase activity IDA
IDA: Inferred from direct assay
1789929 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aldo-keto reductase family 1 member D1

  • 3-oxo-5-beta-steroid 4-dehydrogenase

  • aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)

  • delta(4)-3-ketosteroid 5-beta-reductase

  • delta(4)-3-oxosteroid 5-beta-reductase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-156701 BAY-1128688 / Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-113114 Tetrahydrocortisone Substrate 99.97% Unkown
HY-N8549A 5-Dihydrocortisone 99.83% Unkown
HY-RS00538 AKR1D1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18415 Akr1d1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24896 Akr1d1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akr1d1 NCBI NCBI:6718