Senp1 - SUMO1/sentrin specific peptidase 1 Gene

Also Known as suPr-2; D15Ertd528e; 2310046A20Rik; E330036L07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 223870

Summary

Enables SUMO-specific isopeptidase activity. Acts upstream of or within negative regulation of proteasomal ubiquitin-dependent protein catabolic process; protein desumoylation; and regulation of definitive erythrocyte differentiation. Predicted to be located in focal adhesion; nuclear membrane; and nucleoplasm. Predicted to be active in nucleus. Is expressed in embryo and heart. Used to study type 1 diabetes mellitus. Orthologous to human SENP1 (SUMO specific peptidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Senp1 Products (2)

mRNA Protein Name
NM_001379573.1 NP_001366502.1 sentrin-specific protease 1 isoform 1
NM_144851.5 NP_659100.1 sentrin-specific protease 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables deSUMOylase activity IDA
IDA: Inferred from direct assay
22942423 MGI
enables deSUMOylase activity IMP
IMP: Inferred from mutant phenotype
20233849 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22942423 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
17981124 MGI
acts upstream of proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
17981124 MGI
acts upstream of or within protein desumoylation IDA
IDA: Inferred from direct assay
15767674 MGI
involved in protein desumoylation IDA
IDA: Inferred from direct assay
20233849 MGI
acts upstream of or within protein desumoylation IMP
IMP: Inferred from mutant phenotype
15923632 MGI
acts upstream of or within regulation of definitive erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17981124 MGI
Cellular Component GO Annotation Evidence References Source
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
33113832 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
33113832 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sentrin-specific protease 1

  • SUMO-1 protease 2

  • SUMO1/sentrin specific protease 1

  • sentrin/SUMO-specific protease SENP1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0330 Momordin Ic 99.78% Unkown
HY-N2360 Hinokiflavone 99.81% Unkown
HY-124586 Streptonigrin 99.9% Unkown
HY-103435 Vialinin A 99.90% Unkown
HY-134596 SENP1-IN-3 Inhibitor 99.84% Unkown
HY-134594 SENP1-IN-1 Inhibitor 99.55% Unkown
HY-W013973 p-Terphenyl 99.84% Unkown
HY-151358 SENP2-IN-1 Inhibitor 98.05% Unkown
HY-134597 SENP1-IN-4 Inhibitor 98.0% Unkown
HY-W342380 SPI-05 Inhibitor / Unkown
HY-134595 SENP1-IN-2 Inhibitor / Unkown
HY-RS12671 SENP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16839 Senp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23281 Senp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Senp1 NCBI NCBI:29843