SENP1 - SUMO specific peptidase 1 Gene

Also Known as SuPr-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29843

About SENP1

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:48,042,897-48,106,079 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues and 3 paralogues. Broad expression in testis (RPKM 36.5), lymph node (RPKM 5.6) and 18 other tissues.

Summary

This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

SENP1 Products (2)

mRNA Protein Name
NM_001267594.2 NP_001254523.1 sentrin-specific protease 1
NM_001267595.2 NP_001254524.1 sentrin-specific protease 1

SENP1 Protein Structure

Peptidase_C48

Peptidase_C48: Ulp1 protease family, C-terminal catalytic domain (464 - 634)

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  • 643 a.a.
Protein Preferred Names Protein Names

sentrin-specific protease 1

  • SUMO1/sentrin specific peptidase 1

SENP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SENP1 Q9P0U3 SUMO2 Homo sapiens P61956
Y2H Prey Pooling
32296183
Intra
SENP1 Q9P0U3 SUMO2 Homo sapiens P61956
Y2H Array
32296183
Intra
SENP1 Q9P0U3 SUMO2 Homo sapiens P61956
ITC
17099698
Intra
SENP1 Q9P0U3 SUMO2 Homo sapiens P61956
Enzymatic Study
17099698
Intra
SENP1 Q9P0U3 SUMO2 Homo sapiens P61956
FRET
17099698
Intra
SENP1 Q9P0U3 SUMO1 Homo sapiens P63165
Y2H Prey Pooling
32296183
Intra
SENP1 Q9P0U3 SUMO1 Homo sapiens P63165
Y2H Array
32296183
Intra
SENP1 Q9P0U3 SUMO1 Homo sapiens P63165
CoIP
15896780
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SENP1 Proteins

Cat. No. Product Name Accession Purity
HY-P79459 SENP1 Catalytic Domain Protein, Human (His) Q9P0U3-1 (D415-L644) ≥ 95%, as determined by reducing SDS-PAGE.

SENP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82170 SENP1 Antibody (YA1915) WB, IHC-P, ICC/IF, FC Human

Related Diseases

Diseases Alias
Chronic Mountain Sickness

  • Chronic Mountain Sickness, Susceptibility To

  • Monge Disease

  • Monge'S Disease
Combat Disorder

  • Combat Disorders

  • Combat Neurosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0330 Momordin Ic 99.78% Unkown
HY-N2360 Hinokiflavone 99.81% Unkown
HY-124586 Streptonigrin 99.9% Unkown
HY-103435 Vialinin A 99.90% Unkown
HY-134596 SENP1-IN-3 Inhibitor 99.84% Unkown
HY-134594 SENP1-IN-1 Inhibitor 99.55% Unkown
HY-W013973 p-Terphenyl 99.84% Unkown
HY-151358 SENP2-IN-1 Inhibitor 98.05% Unkown
HY-134597 SENP1-IN-4 Inhibitor 98.0% Unkown
HY-W342380 SPI-05 Inhibitor / Unkown
HY-134595 SENP1-IN-2 Inhibitor / Unkown
HY-RS12671 SENP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16839 Senp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23281 Senp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SENP1 VGNC VGNC:100103
Canis familiaris SENP1 VGNC VGNC:46005
Bos taurus SENP1 VGNC VGNC:34445
Mus musculus SENP1 MGD MGI:2445054
Felis catus SENP1 VGNC VGNC:65002
Rattus norvegicus SENP1 RGD RGD:1310275
Others SENP1 NCBI