Pde6a - phosphodiesterase 6A, cGMP-specific, rod, alpha Gene

Also Known as Pdea; nmf282

Species: Mus musculus

Gene Type: protein coding
Gene ID: 225600

About Pde6a

Chromosome 18: 61,353,387-61,422,995 forward strand.GRCm39:CM001011.3

This gene has 2 transcripts (splice variants), 100 orthologues, 20 paralogues and is associated with 19 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity. Acts upstream of or within photoreceptor cell maintenance and retina development in camera-type eye. Predicted to be located in plasma membrane. Predicted to be active in photoreceptor outer segment membrane. Is expressed in retina outer nuclear layer. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa 43. Orthologous to human PDE6A (phosphodiesterase 6A). [provided by Alliance of Genome Resources, Apr 2022]

Pde6a Products (1)

mRNA Protein Name
NM_146086.3 NP_666198.1 rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within photoreceptor cell maintenance IMP
IMP: Inferred from mutant phenotype
22183357 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
21052544 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pde6a Protein Structure

GAF

GAF: smart00065 (66 - 231)

GAF

GAF: smart00065 (253 - 440)

PDEase_I

PDEase_I: pfam00233 (557 - 801)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 860 a.a.
Protein Preferred Names Protein Names

rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

  • GMP-PDE alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10230 PDE6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10231 Pde6a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10232 Pde6a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde6a NCBI NCBI:5145