Alas2 - 5'-aminolevulinate synthase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25748

Summary

Enables 5-aminolevulinate synthase activity and coenzyme A binding activity. Involved in several processes, including gland development; response to benzene; and response to lead ion. Located in mitochondrion. Biomarker of anemia; bilirubin metabolic disorder; and hemolytic anemia. Human ortholog(s) of this gene implicated in cutaneous porphyria; erythropoietic protoporphyria; hemochromatosis; sideroblastic anemia; and sideroblastic anemia 1. Orthologous to human ALAS2 (5'-aminolevulinate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

Alas2 Products (1)

mRNA Protein Name
NM_013197.1 NP_037329.1 5-aminolevulinate synthase, erythroid-specific, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 5-aminolevulinate synthase activity IDA
IDA: Inferred from direct assay
8407861 RGD
enables coenzyme A binding IDA
IDA: Inferred from direct assay
8407861 RGD
Biological Process GO Annotation Evidence References Source
involved in lactation IEP
IEP: Inferred from expression pattern
18255020 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
6895999 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
18255020 RGD
involved in response to benzene IEP
IEP: Inferred from expression pattern
6895089 RGD
involved in response to cobalt ion IEP
IEP: Inferred from expression pattern
2781150 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
21737922 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
17095594 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
16597373 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16005536 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5-aminolevulinate synthase, erythroid-specific, mitochondrial

  • 5-aminolevulinic acid synthase 2

  • ALAS-E

  • Aminolevulinate synthase 2, delta

  • aminolevulinate, delta-, synthase 2

  • aminolevulinic acid synthase 2, erythroid

  • aminolevulinic acid synthase 2, erythroid-like

  • delta-ALA synthase 2

  • delta-ALA synthetase

  • delta-

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00555 ALAS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19407 Alas2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25899 Alas2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alas2 NCBI NCBI:212