DPY19L2 - dpy-19 like 2 Gene

Also Known as SPGF9; SPATA34

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 283417

About DPY19L2

Cytogenetic location: 12q14.2 Genomic coordinates (GRCh38): 12:63,558,913-63,668,805 (from NCBI)

This gene has 9 transcripts (splice variants), 204 orthologues, 3 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 14.7), heart (RPKM 3.9) and 10 other tissues.

Summary

The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9). [provided by RefSeq, Dec 2011]

DPY19L2 Products (1)

mRNA	Protein	Name
NM_173812.5	NP_776173.3	probable C-mannosyltransferase DPY19L2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in spermatid development	IMP IMP: Inferred from mutant phenotype	21397063	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPY19L2 Protein Structure

Dpy19

0
200
400
600
758 a.a.

Protein Preferred Names	Protein Names
probable C-mannosyltransferase DPY19L2	protein dpy-19 homolog 2

Related Diseases

Diseases	Alias
Spermatogenic Failure 9	Male Infertility Due To Globozoospermia SPGF9 Male Infertility Due To Round-Headed Spermatozoa Globozoospermia, Complete Globozoospermia, Total Globozoospermia Globozoospermia Syndrome Round-Headed Sperm Syndrome Globozoospermia Complete Globozoospermia Total
Infertility
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Spermatogenic Failure 5	Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna SPGF5 Macrocephalic Sperm Head Syndrome Male Infertility Due To Macrozoospermia Infertility Associated With Multitailed Spermatozoa And Excessive Dna Macrozoospermia Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid Large-Headed Multiflagellar Polyploid Spermatozoa Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa
Oligoasthenoteratozoospermia	Oat Oligoasthenoteratospermia
Vas Deferens, Congenital Bilateral Aplasia Of	Congenital Bilateral Absence Of Vas Deferens CBAVD Cavd Congenital Bilateral Aplasia Of Vas Deferens Congenital Bilateral Absence Of The Vas Deferens Congenital Bilateral Agenesis Of Vas Deferens Absence Of Vas Deferens Absent Vasa Congenital Absence Of Vas Deferens Congenital Aplasia Of Vas Deferens Absent Vas Deferens Vas Deferens, Congenital Bilateral Absence
Pelvic Varices	Varix Of Pelvis Pelvic Varicose Vein
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03976	DPY19L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DPY19L2	MGD	MGI:2444662
Rattus norvegicus	DPY19L2	RGD	RGD:1564311
Bos taurus	DPY19L2	VGNC	VGNC:59169
Canis familiaris	DPY19L2	VGNC	VGNC:97188
Others	DPY19L2	NCBI