DPY19L2 - dpy-19 like 2 Gene

Homo sapiens

Also known as SPGF9; SPATA34

Gene ID: 283417 | Gene type: protein coding

About DPY19L2

Cytogenetic location: 12q14.2 Genomic coordinates (GRCh38): 12:63,558,913-63,668,805 (from NCBI)

This gene has 9 transcripts (splice variants), 204 orthologues, 3 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 14.7), heart (RPKM 3.9) and 10 other tissues.

Summary

The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9). [provided by RefSeq, Dec 2011]

DPY19L2 Products(1)

mRNA	Protein	Name
NM_173812.5	NP_776173.3	probable C-mannosyltransferase DPY19L2

DPY19L2 Protein Structure

Dpy19

0
200
400
600
758 a.a.

Protein Preferred Names

Protein Names

probable C-mannosyltransferase DPY19L2

protein dpy-19 homolog 2

Related Diseases

Diseases

Alias

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Infertility

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Spermatogenic Failure 5

Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa	Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna
SPGF5	Macrocephalic Sperm Head Syndrome
Male Infertility Due To Macrozoospermia	Infertility Associated With Multitailed Spermatozoa And Excessive Dna
Macrozoospermia	Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa
Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid	Large-Headed Multiflagellar Polyploid Spermatozoa
Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa

Oligoasthenoteratozoospermia

Oat	Oligoasthenoteratospermia

Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens	CBAVD
Cavd	Congenital Bilateral Aplasia Of Vas Deferens
Congenital Bilateral Absence Of The Vas Deferens	Congenital Bilateral Agenesis Of Vas Deferens
Absence Of Vas Deferens	Absent Vasa
Congenital Absence Of Vas Deferens	Congenital Aplasia Of Vas Deferens
Absent Vas Deferens	Vas Deferens, Congenital Bilateral Absence

Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03976	DPY19L2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DPY19L2	MGD	MGI:2444662
Rattus norvegicus	DPY19L2	RGD	RGD:1564311
Bos taurus	DPY19L2	VGNC	VGNC:59169
Canis familiaris	DPY19L2	VGNC	VGNC:97188

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