Ntrk3 - neurotrophic receptor tyrosine kinase 3 Gene

Also Known as trkC

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29613

About Ntrk3

Primary_assembly 1: 132,132,849-132,503,286 reverse strand.mRatBN7.2:CM026974.1

This gene has 6 transcripts (splice variants), 271 orthologues, 54 paralogues and is associated with 15 phenotypes. Biased expression in Brain (RPKM 154.8), Adrenal (RPKM 34.) and 6 other tissues.

Summary

Enables GPI-linked Ephrin Receptor activity. Involved in several processes, including cellular response to retinoic acid; generation of neurons; and regulation of synapse assembly. Located in cytoplasm and plasma membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach Cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk3 Products (3)

mRNA Protein Name
NM_019248.2 NP_062121.1 NT-3 growth factor receptor isoform 3 precursor
NM_001270656.1 NP_001257585.1 NT-3 growth factor receptor isoform 1 precursor
NM_001270655.1 NP_001257584.1 NT-3 growth factor receptor isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GPI-linked ephrin receptor activity IDA
IDA: Inferred from direct assay
19036963 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17341134 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
10027563 RGD
involved in cochlea development IEP
IEP: Inferred from expression pattern
10494076 RGD
involved in negative regulation of astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
12075995 RGD
involved in neuron fate specification IMP
IMP: Inferred from mutant phenotype
15247919 RGD
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
12075995 RGD
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
8494647 RGD
involved in postsynaptic density assembly EXP
EXP: Inferred from Experiment
21262467 RGD
involved in postsynaptic density assembly IDA
IDA: Inferred from direct assay
21262467 RGD
involved in regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
12075995 RGD
involved in regulation of presynapse assembly IDA
IDA: Inferred from direct assay
21262467 RGD
involved in regulation of presynapse assembly IMP
IMP: Inferred from mutant phenotype
21262467 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
17532148 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
14557907 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
11743997 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
21262467 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21262467 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21262467 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
21262467 RGD
is active in postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
21262467 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ntrk3 Protein Structure

LRRNT

LRRNT: pfam01462 (30 - 50)

LRR_8

LRR_8: pfam13855 (102 - 159)

LRR_1

LRR_1: sd00031 (104 - 127)

LRR_1

LRR_1: sd00031 (128 - 150)

LRR_1

LRR_1: sd00031 (151 - 163)

TPKR_C2

TPKR_C2: pfam16920 (162 - 207)

ig

ig: pfam00047 (213 - 298)

Ig

Ig: cd00096 (226 - 230)

Ig

Ig: cd00096 (239 - 243)

Ig

Ig: cd00096 (265 - 269)

Ig

Ig: cd00096 (280 - 285)

Ig

Ig: cd00096 (293 - 296)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (303 - 395)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (304 - 310)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (312 - 315)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (318 - 326)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (329 - 336)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (339 - 342)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (347 - 353)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (357 - 365)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (373 - 381)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (384 - 392)

PTKc_TrkC

PTKc_TrkC: cd05094 (531 - 856)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 864 a.a.
Protein Preferred Names Protein Names

NT-3 growth factor receptor

  • GP145-TrkC

  • neural receptor protein-tyrosine kinase (trkC)

  • neurotrophic tyrosine kinase, receptor, type 3

  • trk-C

  • trkC tyrosine kinase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-131003 Taletrectinib Inhibitor 99.63% Unkown

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09634 NTRK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W070306 PDK1-IN-1 Inhibitor 99.95% Unkown
HY-131003A Taletrectinib free base Inhibitor / Unkown
HY-101977A (R,S)-Selitrectinib Inhibitor / Unkown
HY-115541 BRD4-IN-41 Inhibitor / Unkown
HY-RS09635 Ntrk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09636 Ntrk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992308 Anti-TrkC Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ntrk3 NCBI NCBI:4916