Ntrk3 - neurotrophic receptor tyrosine kinase 3 Gene

Rattus norvegicus

Also known as trkC

Gene ID: 29613 | Gene type: protein coding

About Ntrk3

Primary_assembly 1: 132,132,849-132,503,286 reverse strand.mRatBN7.2:CM026974.1

This gene has 6 transcripts (splice variants), 271 orthologues, 54 paralogues and is associated with 15 phenotypes. Biased expression in Brain (RPKM 154.8), Adrenal (RPKM 34.) and 6 other tissues.

Summary

Enables GPI-linked Ephrin Receptor activity. Involved in several processes, including cellular response to retinoic acid; generation of neurons; and regulation of synapse assembly. Located in cytoplasm and plasma membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach Cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk3 Products(3)

mRNA	Protein	Name
NM_019248.2	NP_062121.1	NT-3 growth factor receptor isoform 3 precursor
NM_001270656.1	NP_001257585.1	NT-3 growth factor receptor isoform 1 precursor
NM_001270655.1	NP_001257584.1	NT-3 growth factor receptor isoform 2 precursor

Ntrk3 Protein Structure

LRRNT

LRR_8

LRR_1

TPKR_C2

IgI_TrKABC_d5

PTKc_TrkC

0
200
400
600
800
864 a.a.

Protein Preferred Names

Protein Names

NT-3 growth factor receptor

GP145-TrkC	neural receptor protein-tyrosine kinase (trkC)
neurotrophic tyrosine kinase, receptor, type 3	trk-C
trkC tyrosine kinase

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-131003	Taletrectinib	Inhibitor	99.78%	Phase 2
HY-131003A	Taletrectinib free base	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS09634	NTRK3 Human Pre-designed siRNA Set A	/	Unkown
HY-RS09635	Ntrk3 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS09636	Ntrk3 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ntrk3	NCBI	NCBI:4916

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