Kcnq3 - potassium voltage-gated channel subfamily Q member 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29682

Summary

Enables several functions, including Calmodulin binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in cellular response to ammonium ion; nervous system development; and potassium ion transmembrane transport. Located in several cellular components, including axon initial segment; membrane raft; and neuronal cell body. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Human ortholog(s) of this gene implicated in autistic disorder and benign neonatal seizures. Orthologous to human KCNQ3 (potassium voltage-gated channel subfamily Q member 3). [provided by Alliance of Genome Resources, Apr 2022]

Kcnq3 Products (1)

mRNA Protein Name
NM_031597.5 NP_113785.4 potassium voltage-gated channel subfamily KQT member 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calmodulin binding IDA
IDA: Inferred from direct assay
24333508 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
15304482 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
24333508 RGD
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
17322297 RGD
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
9836639 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to ammonium ion IMP
IMP: Inferred from mutant phenotype
24333508 RGD
involved in ganglion development IEP
IEP: Inferred from expression pattern
12832524 RGD
involved in monoatomic ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
15304482 RGD
involved in oligodendrocyte development IEP
IEP: Inferred from expression pattern
21750731 RGD
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
9836639 RGD
Cellular Component GO Annotation Evidence References Source
located in axon initial segment IDA
IDA: Inferred from direct assay
24333508 RGD
located in cell surface IDA
IDA: Inferred from direct assay
15304482 RGD
located in dendrite IDA
IDA: Inferred from direct assay
24333508 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12832524 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
9836639 RGD
located in somatodendritic compartment IDA
IDA: Inferred from direct assay
24333508 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
9836639 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily KQT member 3

  • KQT-like 3

  • potassium channel subunit alpha KvLQT3

  • potassium channel, voltage-gated KQT-like subfamily Q, member 3

  • potassium voltage-gated channel, KQT-like subfamily, member 3

  • voltage-gated potassium channel subunit Kv7.3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108577 XE991 dihydrochloride Inhibitor 99.97% Unkown
HY-122114 ICA-27243 Activator 98.74% Unkown
HY-108577A XE991 Inhibitor 99.69% Unkown
HY-130070 QO-40 Activator 98.77% Unkown
HY-184207 Zinc13732787 Inhibitor / Unkown
HY-RS07175 KCNQ3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19700 Kcnq3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26195 Kcnq3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnq3 NCBI NCBI:3786