2. Gene
  3. Pde6a - phosphodiesterase 6A Gene

Pde6a - phosphodiesterase 6A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 307401 | Gene type: protein coding

About Pde6a

Primary_assembly 18: 54,676,863-54,748,816 forward strand.mRatBN7.2:CM026991.1

This gene has 1 transcript (splice variant), 100 orthologues, 20 paralogues and is associated with 8 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity. Predicted to be involved in retina development in camera-type eye and signal transduction. Predicted to act upstream of or within photoreceptor cell maintenance. Predicted to be active in photoreceptor outer segment membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 43. Orthologous to human PDE6A (phosphodiesterase 6A). [provided by Alliance of Genome Resources, Apr 2022]

Pde6a Products(1)

mRNA Protein Name
NM_001107386.2 NP_001100856.1 rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Pde6a Protein Structure

GAF

GAF: smart00065 (79 - 231)

GAF

GAF: smart00065 (253 - 440)

PDEase_I

PDEase_I: pfam00233 (557 - 801)

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  • 860 a.a.
Protein Preferred Names Protein Names

rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

phosphodiesterase 6A, cGMP-specific, rod, alpha

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10230 PDE6A Human Pre-designed siRNA Set A / Unkown
HY-RS10231 Pde6a Mouse Pre-designed siRNA Set A / Unkown
HY-RS10232 Pde6a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde6a NCBI NCBI:5145