HLA-DPA1 - major histocompatibility complex, class II, DP alpha 1 Gene

Also Known as DPA1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DPA; HLA-DP1A; HLA-DPB1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3113

About HLA-DPA1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,064,569-33,080,748 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 67 orthologues, 13 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 361.8), spleen (RPKM 361.5) and 24 other tissues.

Summary

HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

HLA-DPA1 Products (4)

mRNA Protein Name
NM_001242524.2 NP_001229453.1 HLA class II histocompatibility antigen, DP alpha 1 chain precursor
NM_001242525.2 NP_001229454.1 HLA class II histocompatibility antigen, DP alpha 1 chain precursor
NM_001405020.1 NP_001391949.1 HLA class II histocompatibility antigen, DP alpha 1 chain precursor
NM_033554.4 NP_291032.2 HLA class II histocompatibility antigen, DP alpha 1 chain precursor
Protein Preferred Names Protein Names

HLA class II histocompatibility antigen, DP alpha 1 chain

  • HLA DPA1

Recombinant HLA-DPA1 Proteins

Cat. No. Product Name Accession Purity
HY-P71697 HLA-DPA1 Protein, Human (His) P20036 (A29-E222) ≥ 90%, as determined by reducing SDS-PAGE.

HLA-DPA1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81436 HLA-DPA1 Antibody (YA1181) IHC-P Human
HY-P81436A HLA-DPA1 Antibody (YA1181)(PBS only) IHC-P Human
HY-P84161 HLA-DPA1 Antibody (YA3858) WB, IHC-P, FC, ELISA Human
HY-P84161A HLA-DPA1 Antibody (YA3858)(PBS only) WB, IHC-P, FC, ELISA Human
HY-P84162 HLA-DPA1 Antibody (YA3859) IHC-P, FC, ELISA Human, Rat
HY-P84162A HLA-DPA1 Antibody (YA3859)(PBS only) IHC-P, FC, ELISA Human, Rat

Related Diseases

Diseases Alias
Berylliosis

  • Beryllium Poisoning

  • Beryllium Disease

  • Lung Fibrosis With Berylliosis
Granulomatosis With Polyangiitis

  • GPA

  • Wegener Granulomatosis

  • Wegener Granulomatosis, Formerly

  • Midline Granulomatosis

  • Wg, Formerly

  • Necrotizing Respiratory Granulomatosis

  • Wg

  • Wegeners Granulomatosis

  • Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Rubella

  • German Measles

  • Three Day Measles

  • Rubella Nos
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Chromophobe Renal Cell Carcinoma

  • Chromophobe Adenocarcinoma

  • Chromophobe Carcinoma Of Kidney

  • Kidney Chromophobe

  • Renal Cell Carcinoma, Chromophobe Cell

  • Crcc

  • Chrcc

  • Chromophobe Renal Cell Adenocarcinoma

  • Chromophobe Renal Carcinoma

  • Chromophobe Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06203 HLA-DPA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HLA-DPA1 RGD RGD:1595921