Auts2 - autism susceptibility candidate 2 Gene

Predicted to enable chromatin binding activity. Involved in several processes, including generation of neurons; positive regulation of Rac protein signal transduction; and positive regulation of lamellipodium assembly. Acts upstream of or within innate vocalization behavior and righting reflex. Located in growth cone and nucleus. Colocalizes with actin Cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study autosomal dominant non-syndromic intellectual disability and autosomal dominant non-syndromic intellectual disability 26. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 26. Orthologous to human AUTS2 (activator of transcription and developmental regulator AUTS2). [provided by Alliance of Genome Resources, Apr 2022]