Fan1 - FANCD2/FANCI-associated nuclease 1 Gene

Enables 5'-3' exonuclease activity. Predicted to be involved in double-strand break repair via homologous recombination; interstrand cross-link repair; and nucleotide-excision repair, DNA incision. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in cytosol; intercellular bridge; and nucleoplasm. Predicted to be active in nucleus. Is expressed in ductus deferens; epididymis; and testis. Used to study karyomegalic interstitial nephritis. Human ortholog(s) of this gene implicated in karyomegalic interstitial nephritis. Orthologous to human FAN1 (FANCD2 and FANCI associated nuclease 1). [provided by Alliance of Genome Resources, Apr 2022]