UNCX - UNC homeobox Gene

Also Known as UNCX4.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 340260

About UNCX

This gene has 1 transcript (splice variant), 249 orthologues and 50 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a homeobox transcription factor that is involved in somitogenesis and neurogenesis and is required for the maintenance and differentiation of specific elements of the axial skeleton. This gene also plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and deliver Hormones that control peripheral functions. The expression of this gene is associated with an increased frequency of acute myeloid leukemia. [provided by RefSeq, Jul 2017]

UNCX Products (1)

mRNA Protein Name
NM_001080461.3 NP_001073930.1 homeobox protein unc-4 homolog

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNCX Protein Structure

Homeobox

Homeobox: Homeobox domain (106 - 162)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 531 a.a.
Protein Preferred Names Protein Names

homeobox protein unc-4 homolog

  • UNC homeobox protein

Related Diseases

Diseases Alias
Spondylocostal Dysostosis

  • Jarcho-Levin Syndrome

  • Costovertebral Dysplasia

  • Spondylothoracic Dysostosis

  • Spondylothoracic Dysplasia

  • Scdo

  • Dysostosis, Spondylocostal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15477 UNCX Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UNCX MGD MGI:108013
Rattus norvegicus UNCX RGD RGD:69361
Macaca mulatta UNCX VGNC VGNC:81789
Felis catus UNCX VGNC VGNC:107827
Canis familiaris UNCX VGNC VGNC:48146
Bos taurus UNCX VGNC VGNC:58424
Others UNCX NCBI