Tial1 - Tia1 cytotoxic granule-associated RNA binding protein-like 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 361655

Summary

Predicted to enable mRNA 3'-UTR AU-rich region binding activity and mRNA binding activity involved in posttranscriptional gene silencing. Predicted to be involved in negative regulation of cell population proliferation; positive regulation of gene silencing by miRNA; and positive regulation of hippo signaling. Predicted to act upstream of or within germ cell development; positive regulation of cell population proliferation; and stem cell division. Located in cytoplasmic stress granule and nucleus. Part of ribonucleoprotein complex. Biomarker of transient cerebral ischemia. Orthologous to human TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1). [provided by Alliance of Genome Resources, Apr 2022]

Tial1 Products (1)

mRNA Protein Name
NM_001013193.1 NP_001013211.1 nucleolysin TIAR

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
22555848 RGD
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
12855701 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleolysin TIAR

  • RNA binding protein TIAR (TIA-1 related)

  • Tial 1 cytotoxic granule-associated RNA- binding protein-like 1

  • Tial1 cytotoxic granule-associated RNA binding protein-like 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116079 Diplopterol / Unkown
HY-117733 Zerumin A Inhibitor / Unkown
HY-RS14514 TIAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14520 TIE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-15973 BSF-466895 Inhibitor / Unkown
HY-RS19390 Tie1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22860 Tial1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25882 Tie1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29374 Tial1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991384 DX-2240 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tial1 NCBI NCBI:7073