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  2. ITGAD - integrin subunit alpha D Gene

ITGAD - integrin subunit alpha D Gene

Homo sapiens

Also known as ADB2; CD11D

Gene ID: 3681 | Gene type: protein coding

About ITGAD

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,393,335-31,426,505 (from NCBI)

This gene has 3 transcripts (splice variants), 113 orthologues and 17 paralogues. Biased expression in spleen (RPKM 11.2), lymph node (RPKM 2.1) and 2 other tissues.

Summary

This gene belongs to the beta-2 Integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the Integrin subunit alpha X gene, another member of the Integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

ITGAD Products(2)

mRNA Protein Name
NM_001318185.2 NP_001305114.1 integrin alpha-D isoform 1 precursor
NM_005353.3 NP_005344.2 integrin alpha-D isoform 2 precursor

ITGAD Protein Structure

VWA

VWA: von Willebrand factor type A domain (150 - 328)

Integrin_alpha2

Integrin_alpha2: Integrin alpha (614 - 1001)

Integrin_alpha

Integrin_alpha: Integrin alpha cytoplasmic region (1124 - 1137)

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  • 1161 a.a.
Protein Preferred Names Protein Names

integrin alpha-D

CD11 antigen-like family member D

Related Diseases

Diseases Alias
Leukocyte Adhesion Deficiency, Type I

Leukocyte Adhesion Deficiency

Leukocyte Adhesion Deficiency 1

LAD1

Lad

Lymphocyte Function-Associated Antigen 1 Immunodeficiency

Leukocyte Adhesion Deficiency Type I

Leukocyte Adhesion Deficiency Type 1

Linear Iga Bullous Dermatosis

Linear Iga Dermatosis

Leukocyte-Adhesion Deficiency Syndrome

Lfa1 Immunodeficiency

Congenital Leukocyte Adherence Deficiency

Lad-I

Linear Iga Disease

Leukocyte Adhesion Deficiency Syndrome

Lad 1

Lfa 1 Immunodeficiency

Linear Immunoglobulin A Dermatosis

Leucocyte Adhesion Deficiency Type 1

Leukocyte Adhesion Molecule Deficiency Type 1

Chronic Monocytic Leukemia

Leukemia, Myeloid

Leukemia, Monocytic, Chronic

Leukocyte Adhesion Deficiency, Type Iii

Leukocyte Adhesion Deficiency 3

LAD3

Leukocyte Adhesion Deficiency 1 Variant

Lad1v

Integrin Activation Deficiency Disease

Iadd

Leukocyte Adhesion Deficiency Type Iii

Lad1 Variant

Lad-1 Variant

Lad-Iii

Leukocyte Adhesion Deficiency-1 Variant

Leukocyte Adhesion Deficiency Type 1

Histiocytic And Dendritic Cell Cancer

Histiocytic And Dendritic Cell

Histiocytic Sarcoma

Malignant Histiocytosis

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia

Spinal Muscular Atrophy, Type Iv

SMA4

Spinal Muscular Atrophy, Adult Form

Spinal Muscular Atrophy 4

Spinal Muscular Atrophy-4

Adult Spinal Muscular Atrophy

Spinal Muscular Atrophy, Proximal, Adult, Autosomal Recessive

Proximal Spinal Muscular Atrophy Type 4

Sma Type 4

Sma Type Iv

Sma-Iv

Sma Iv

Spinal Muscular Atrophy Adult Form

Spinal Muscular Atrophy Proximal Adult Autosomal Recessive

Spinal Muscular Atrophy Type Iv

Atrophy, Muscular, Spinal, Type Iv

Myelopathic Muscular Atrophy

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus ITGAD VGNC VGNC:55055
Mus musculus ITGAD MGD MGI:3578624
Rattus norvegicus ITGAD RGD RGD:71075