SUMO4 - small ubiquitin like modifier 4 Gene

Also Known as IDDM5; SMT3H4; SUMO-4; dJ281H8.4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 387082

About SUMO4

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,400,262-149,401,278 (from NCBI)

This gene has 1 transcript (splice variant), 90 orthologues, 3 paralogues and is associated with 1 phenotype.

Summary

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]

SUMO4 Products (1)

mRNA Protein Name
NM_001002255.2 NP_001002255.1 small ubiquitin-related modifier 4

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
16236267 GOA
involved in negative regulation of DNA binding IDA
IDA: Inferred from direct assay
16236267 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15247916 GOA
involved in positive regulation of DNA binding IDA
IDA: Inferred from direct assay
16236267 GOA
involved in protein sumoylation IDA
IDA: Inferred from direct assay
15247916 GOA
involved in regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
15247916 GOA
involved in regulation of protein localization to nucleus IDA
IDA: Inferred from direct assay
16236267 GOA
Cellular Component GO Annotation Evidence References Source
part of SUMO ligase complex IDA
IDA: Inferred from direct assay
16236267 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUMO4 Protein Structure

Rad60-SLD

Rad60-SLD: Ubiquitin-2 like Rad60 SUMO-like (18 - 86)

  • 0
  • 95 a.a.
Protein Preferred Names Protein Names

small ubiquitin-related modifier 4

  • SMT3 suppressor of mif two 3 homolog 2

SUMO4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82876 SUMO4 Antibody (YA2621) WB, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Type 1 Diabetes Mellitus 5

  • Diabetes Mellitus, Insulin-Dependent, 5

  • Latent Autoimmune Diabetes In Adults

  • IDDM5

  • Insulin-Dependent Diabetes Mellitus 5

  • T1D5

  • Lada

  • Type 1.5 Diabetes

  • Diabetes Mellitus, Insulin-Dependent, Type 5
Diabetes Mellitus

  • Diabetes
Type 1 Diabetes Mellitus

  • Diabetes Mellitus, Insulin-Dependent

  • Diabetes Mellitus Type 1

  • IDDM

  • Type 1 Diabetes

  • Insulin-Dependent Diabetes Mellitus

  • T1D

  • Juvenile-Onset Diabetes

  • Jod

  • Diabetes Mellitus, Type 1

  • Diabetes Mellitus, Insulin-Dependent-1

  • Type I Diabetes Mellitus

  • Autoimmune Diabetes

  • Juvenile Diabetes

  • Juvenile-Onset Diabetes Mellitus

  • Diabetes, Insulin Dependent

  • Insulin-Dependent Diabetes Mellitus-1

  • Diabetes Mellitus Insulin-Dependent

  • Diabetes Autoimmune

  • Diabetes Mellitus, Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 1, Susceptibility To

  • Diabetes Type 1

  • Type I Diabetes

  • Diabetes, Autoimmune

  • T1dm - [Type 1 Diabetes Mellitus]

  • Iddm - [Insulin Dependent Diabetes Mellitus]

  • Type 1 Iddm

  • Juvenile Diabetes Mellitus Without Compications

  • Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

  • Juvenile-Onset Diabetes Mellitus Without Compications

  • Ketosis-Prone Diabetes Mellitus Without Compications

  • Juvenile-Onset-Type Diabetes Mellitus Without Compications
Meier-Gorlin Syndrome 8

  • MGORS8
Parkinson Disease 7, Autosomal Recessive Early-Onset

  • Autosomal Recessive Early-Onset Parkinson Disease 7

  • PARK7

  • Parkinson'S Disease 7

  • Autosomal Recessive Early-Onset Parkinson'S Disease 7

  • Parkinson Disease 7

  • Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Type 2

  • Autosomal Recessive Early-Onset Parkinson Disease Type 7

  • Parkinson Disease, Type 7
Type 1 Diabetes Mellitus 2

  • Diabetes Mellitus, Noninsulin-Dependent, 1

  • Diabetes Mellitus, Insulin-Dependent, 2

  • IDDM2

  • Insulin-Dependent Diabetes Mellitus 2

  • NIDDM1

  • Diabetes Mellitus, Noninsulin-Dependent 1

  • T1D2

  • Type 2 Diabetes Mellitus 1

  • T2D1

  • Noninsulin-Dependent Diabetes Mellitus 1

  • Diabetes Mellitus, Non-Insulin-Dependent, 1

  • Type 2 Diabetes Mellitus 1, Susceptibility To

  • Diabetes Mellitus, Insulin-Dependent, Type 2

  • Diabetes Mellitus, Non-Insulin-Dependent
Behcet Syndrome

  • Behcet Disease

  • Behcet'S Syndrome

  • Behcet'S Disease

  • Behçet Disease

  • Bd

  • Adamantiades-Behcet Disease

  • Triple Symptom Complex

  • Behçet'S Disease

  • Behet'S Syndrome

  • Bd Syndrome

  • Behçet Syndrome

  • Behçet'S Syndrome

  • Behcet Triple Symptom Complex

  • Malignant Aphthosis

  • Old Silk Route Disease

  • Adamantiades-Behçet Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14028 SUMO4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SUMO4 RGD RGD:41241227