SUMO4 - small ubiquitin like modifier 4 Gene

Homo sapiens

Also known as IDDM5; SMT3H4; SUMO-4; dJ281H8.4

Gene ID: 387082 | Gene type: protein coding

About SUMO4

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,400,262-149,401,278 (from NCBI)

This gene has 1 transcript (splice variant), 90 orthologues, 3 paralogues and is associated with 1 phenotype.

Summary

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]

SUMO4 Products(1)

mRNA	Protein	Name
NM_001002255.2	NP_001002255.1	small ubiquitin-related modifier 4

SUMO4 Protein Structure

Rad60-SLD

0
95 a.a.

Protein Preferred Names

Protein Names

small ubiquitin-related modifier 4

SMT3 suppressor of mif two 3 homolog 2

Related Diseases

Diseases

Alias

Type 1 Diabetes Mellitus 5

Diabetes Mellitus, Insulin-Dependent, 5	Latent Autoimmune Diabetes In Adults
IDDM5	Insulin-Dependent Diabetes Mellitus 5
T1D5	Lada
Type 1.5 Diabetes	Diabetes Mellitus, Insulin-Dependent, Type 5

Diabetes Mellitus

Diabetes

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Meier-Gorlin Syndrome 8

MGORS8

Parkinson Disease 7, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 7	PARK7
Parkinson'S Disease 7	Autosomal Recessive Early-Onset Parkinson'S Disease 7
Parkinson Disease 7	Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Type 2
Autosomal Recessive Early-Onset Parkinson Disease Type 7	Parkinson Disease, Type 7

Type 1 Diabetes Mellitus 2

Diabetes Mellitus, Noninsulin-Dependent, 1	Diabetes Mellitus, Insulin-Dependent, 2
IDDM2	Insulin-Dependent Diabetes Mellitus 2
NIDDM1	Diabetes Mellitus, Noninsulin-Dependent 1
T1D2	Type 2 Diabetes Mellitus 1
T2D1	Noninsulin-Dependent Diabetes Mellitus 1
Diabetes Mellitus, Non-Insulin-Dependent, 1	Type 2 Diabetes Mellitus 1, Susceptibility To
Diabetes Mellitus, Insulin-Dependent, Type 2	Diabetes Mellitus, Non-Insulin-Dependent

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14028	SUMO4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SUMO4	RGD	RGD:41241227

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