ARL2 - ADP ribosylation factor like GTPase 2 Gene

Also Known as ARFL2; MRCS1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 402

About ARL2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,014,160-65,022,184 (from NCBI)

This gene has 6 transcripts (splice variants), 188 orthologues, 30 paralogues and is associated with 2 phenotypes. Ubiquitous expression in kidney (RPKM 49.3), fat (RPKM 49.1) and 25 other tissues.

Summary

This gene encodes a small GTP-binding protein of the Ras superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]

ARL2 Products (2)

mRNA	Protein	Name
NM_001199745.2	NP_001186674.1	ADP-ribosylation factor-like protein 2 isoform 2
NM_001667.4	NP_001658.2	ADP-ribosylation factor-like protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IMP IMP: Inferred from mutant phenotype	10831612	GOA
enables GTPase activity	IMP IMP: Inferred from mutant phenotype	10831612	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10831612	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	16525022	GOA
involved in maintenance of protein location in nucleus	IDA IDA: Inferred from direct assay	18234692	GOA
involved in negative regulation of GTPase activity	IDA IDA: Inferred from direct assay	10831612	GOA
involved in positive regulation of microtubule polymerization	IDA IDA: Inferred from direct assay	10831612	GOA
involved in regulation of aerobic respiration	IMP IMP: Inferred from mutant phenotype	30945270	GOA
involved in regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	30945270	GOA
involved in regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	16525022	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	16525022	GOA
NOT located in cilium	IDA IDA: Inferred from direct assay	17646400	GOA
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	11809823	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	30945270	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18234692	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL2 Protein Structure

Arf

0
100
184 a.a.

Protein Preferred Names	Protein Names
ADP-ribosylation factor-like protein 2	ADP-ribosylation factor-like 2

ARL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARL2	P36404	LHX4	Homo sapiens	Q969G2	Y2H Prey Pooling	32296183
Intra	ARL2	P36404	LHX4	Homo sapiens	Q969G2	Validated Y2H	32296183
Intra	ARL2	P36404	LHX4	Homo sapiens	Q969G2	Y2H Array	32296183
Intra	ARL2	P36404	ARL2BP	Homo sapiens	Q9Y2Y0	Y2H	27107012
Intra	ARL2	P36404	ARL2BP	Homo sapiens	Q9Y2Y0	Validated Y2H	32296183
Intra	ARL2	P36404	ARL2BP	Homo sapiens	Q9Y2Y0	Y2H Array	25416956
Intra	ARL2	P36404	ARL2BP	Homo sapiens	Q9Y2Y0	Y2H Array	32296183
Intra	ARL2	P36404	ARL2BP	Homo sapiens	Q9Y2Y0	MAPPIT	25416956
Intra	ARL2	P36404	ARL2BP	Homo sapiens	Q9Y2Y0	SLC	27107012
Intra	ARL2	P36404	ARL2BP	Homo sapiens	Q9Y2Y0	Y2H Prey Pooling	32296183
Intra	ARL2	P36404	ARL2BP	Homo sapiens	Q9Y2Y0	BFG-2H	27107012
Intra	ARL2	P36404	ARL2BP	Homo sapiens	Q9Y2Y0	BRET	29997244
Intra	ARL2	P36404	ARL2BP	Homo sapiens	Q9Y2Y0	Y2H Array	31515488
Intra	ARL2	P36404	ARL2BP	Homo sapiens	Q9Y2Y0	Y2H Array	25502805
Intra	ARL2	P36404	ARL2BP	Homo sapiens	Q9Y2Y0	Validated Y2H	25416956
Intra	ARL2	P36404	TBCD	Homo sapiens	Q9BTW9	Pull Down	18588884
Intra	ARL2	P36404	TBCD	Homo sapiens	Q9BTW9	Anti Tag CoIP	33961781
Intra	ARL2	P36404	TBCD	Homo sapiens	Q9BTW9	Anti Tag CoIP	35271311
Intra	ARL2	P36404	UNC119	Homo sapiens	Q13432	Y2H Array	25416956
Intra	ARL2	P36404	UNC119	Homo sapiens	Q13432	Validated Y2H	32296183
Intra	ARL2	P36404	UNC119	Homo sapiens	Q13432	Pull Down	18588884
Intra	ARL2	P36404	PDE6D	Homo sapiens	O43924	Pull Down	18588884
Intra	ARL2	P36404	PDE6D	Homo sapiens	O43924	Y2H Prey Pooling	25416956
Intra	ARL2	P36404	PDE6D	Homo sapiens	O43924	Validated Y2H	25416956
Intra	ARL2	P36404	PDE6D	Homo sapiens	O43924	MAPPIT	25416956
Intra	ARL2	P36404	PDE6D	Homo sapiens	O43924	BFG-2H	27107012
Intra	ARL2	P36404	PDE6D	Homo sapiens	O43924	Y2H Pooling	16189514
Intra	ARL2	P36404	PDE6D	Homo sapiens	O43924	Validated Y2H	27107012
Intra	ARL2	P36404	PDE6D	Homo sapiens	O43924	FPS	18588884
Intra	ARL2	P36404	TBL1XR1	Homo sapiens	Q9BZK7	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Microcornea, Rod-Cone Dystrophy, Cataract, And Posterior Staphyloma 1	MRCS1
Cone Dystrophy	Retinal Cone Dystrophy Dystrophy, Cone Cone Dystrophy 3
Retinitis Pigmentosa 2	RP2 X-Linked Retinitis Pigmentosa 2 Xlrp2 Xlrp-2 Retinitis Pigmentosa-2 Retinitis Pigmentosa, Type 2
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Retinitis Pigmentosa 3	RP3 Retinitis Pigmentosa 15 Rp15 Choroidoretinal Degeneration With Retinal Reflex In Heterozygous Women Cone-Rod Degeneration, X-Linked Retinitis Pigmentosa Type 15 X-Linked Cone-Rod Degeneration X-Linked Retinitis Pigmentosa 3 Xlrp3 Xlrp-3 Retinitis Pigmentosa-3 Retinitis Pigmentosa, Type 3
Hypoparathyroidism-Retardation-Dysmorphism Syndrome	Sanjad-Sakati Syndrome Hrd Syndrome HRDS Hypoparathyroidism-Intellectual Disability-Dysmorphism Syndrome Hypoparathyroidism-Short Stature-Intellectual Disability-Seizures Syndrome Richardson-Kirk Syndrome Sss Hypoparathyroidism With Short Stature, Mental Retardation, And Seizures Hypoparathyroidism, Congenital, Associated With Dysmorphism, Growth Retardation, And Developmental Delay Hypoparathyroidism With Short Stature, Mental Retardation And Seizures Hypoparathyroidism With Short Stature, Intellectual Disability And Seizures Hypoparathyroidism, Congenital, Associated With Dysmorphism, Growth Retardation And Developmental Delay
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122641	Deltasonamide 1	Inhibitor	99.15%	Unkown
HY-RS00985	ARL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-122641D	Deltasonamide 1 TFA	Inhibitor	99.70%	Unkown
HY-RS00986	ARL2BP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20252	Arl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21093	Arl2bp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26760	Arl2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27611	Arl2bp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARL2	MGD	MGI:1928393
Rattus norvegicus	ARL2	RGD	RGD:69326
Macaca mulatta	ARL2	VGNC	VGNC:99549
Bos taurus	ARL2	VGNC	VGNC:97240
Others	ARL2	NCBI