Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex

  • FEBS Lett. 2008 Jul 23;582(17):2501-7. doi: 10.1016/j.febslet.2008.05.053.
Stefan Veltel  1 ,  Aleksandra Kravchenko ,  Shehab Ismail ,  Alfred Wittinghofer
Affiliations
  • 1. Max-Planck-Institut für molekulare Physiologie, Abteilung Strukturelle Biologie, Otto-Hahn-Strasse 11, Dortmund, Germany.
PMID: 18588884 DOI: 10.1016/j.febslet.2008.05.053
Abstract

Arl2 and Arl3, members of the Arf subfamily of small G proteins, are believed to be involved in ciliary and microtubule-dependent processes. Recently, we could identify RP2, responsible for a variant of X-linked retinitis pigmentosa, as the Arl3-specific GAP. Here, we have characterized Arl2/3 interactions. We show the formation of a ternary complex between Arl3, its cognate GAP RP2 and its retinal effector HRG4. This complex seems to be important for photoreceptor function.