Icosl - icos ligand Gene

Also Known as B7h; GI50; GL50; B7-H2; LICOS; B7RP-1; GL50-B; ICOS-L; Icoslg; Ly115l; mKIAA0653

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50723

Summary

Predicted to enable identical protein binding activity and signaling receptor binding activity. Involved in positive regulation of interleukin-4 production. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including extraembryonic component; gonad; hemolymphoid system gland; liver; and stomach. Orthologous to human ICOSLG (inducible T cell costimulator ligand). [provided by Alliance of Genome Resources, Apr 2022]

Icosl Products (1)

mRNA Protein Name
NM_015790.3 NP_056605.1 ICOS ligand precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10657606 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of interleukin-4 production IMP
IMP: Inferred from mutant phenotype
11343123 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
10657606 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10657606 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ICOS ligand

  • B7 homolog 2

  • B7-like protein Gl50

  • B7-related protein 1

Recombinant Icosl Proteins

Cat. No. Product Name Accession Purity
HY-P73119 B7-H2/ICOSLG Protein, Mouse (HEK293, His-Fc) Q9JHJ8-1 (E47-K279) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73120 B7-H2/ICOSLG Protein, Mouse (HEK293, His) Q9JHJ8-1 (E47-K279) ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99414 Prezalumab Inhibitor 99.41% Phase 2
HY-P99893 Rozibafusp alfa Inhibitor 96.98% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162810 ICOS-IN-1 / Unkown
HY-RS06521 ICOSLG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25047 Icoslg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990123 Anti-Mouse ICOSL/CD275 Antibody (HK5.3) Inhibitor 98.59% Unkown
HY-P990234 Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) Inhibitor / Unkown
HY-P990235 Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) Inhibitor / Unkown