2. Gene
  3. CHRNA10 - cholinergic receptor nicotinic alpha 10 subunit Gene

CHRNA10 - cholinergic receptor nicotinic alpha 10 subunit Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 57053 | Gene type: protein coding

About CHRNA10

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:3,665,587-3,671,384 (from NCBI)

This gene has 4 transcripts (splice variants), 135 orthologues and 45 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable acetylcholine-gated cation-selective channel activity. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be located in membrane. Predicted to be active in cholinergic synapse and neuron projection. Predicted to be integral component of postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Apr 2022]

CHRNA10 Products(3)

mRNA Protein Name
NM_001303034.2 NP_001289963.1 neuronal acetylcholine receptor subunit alpha-10 isoform b
NM_001303035.2 NP_001289964.1 neuronal acetylcholine receptor subunit alpha-10 isoform b
NM_020402.4 NP_065135.2 neuronal acetylcholine receptor subunit alpha-10 isoform a precursor

CHRNA10 Protein Structure

Neur_chan_LBD

Neur_chan_LBD: Neurotransmitter-gated ion-channel ligand binding domain (32 - 235)

Neur_chan_memb

Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (243 - 374)

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  • 450 a.a.
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit alpha-10

NACHR alpha-10

Related Diseases

Diseases Alias
Tobacco Addiction

Nicotine Dependence

Tobacco Addiction, Susceptibility To

Nicotine Addiction

Tobacco Use Disorder

Smoking Habit

Nicotine Dependence, Protection Against

Nicotine Addiction, Protection From

Cigarette Habituation

Cigarette Habituation, Susceptibility To

Smoking Habit, Susceptibility To

Nicotine Dependence, Susceptibility To

Nicotine Addiction, Susceptibility To

Addiction, Tobacco, Susceptibility To

Compulsive Tobacco User Syndrome

Tobacco Dependence

Tobacco Dependence Syndrome

Cigarette Addiction

Cigarette Dependence

Smoking Addiction

Smokers Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02666 CHRNA10 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CHRNA10 VGNC VGNC:27323
Felis catus CHRNA10 VGNC VGNC:81999
Mus musculus CHRNA10 MGD MGI:3609260
Macaca mulatta CHRNA10 VGNC VGNC:100914
Canis familiaris CHRNA10 VGNC VGNC:57392
Rattus norvegicus CHRNA10 RGD RGD:620142