CHRNA10 - cholinergic receptor nicotinic alpha 10 subunit Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57053

About CHRNA10

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:3,665,587-3,671,384 (from NCBI)

This gene has 4 transcripts (splice variants), 135 orthologues and 45 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable acetylcholine-gated cation-selective channel activity. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be located in membrane. Predicted to be active in cholinergic synapse and neuron projection. Predicted to be integral component of postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Apr 2022]

CHRNA10 Products (3)

mRNA Protein Name
NM_001303034.2 NP_001289963.1 neuronal acetylcholine receptor subunit alpha-10 isoform b
NM_001303035.2 NP_001289964.1 neuronal acetylcholine receptor subunit alpha-10 isoform b
NM_020402.4 NP_065135.2 neuronal acetylcholine receptor subunit alpha-10 isoform a precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of cytosolic calcium ion concentration IGI
IGI: Inferred from genetic interaction
18420419 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHRNA10 Protein Structure

Neur_chan_LBD

Neur_chan_LBD: Neurotransmitter-gated ion-channel ligand binding domain (32 - 235)

Neur_chan_memb

Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (243 - 374)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 450 a.a.
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit alpha-10

  • NACHR alpha-10

CHRNA10 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P84785 CHRNA10 Antibody (YA4482) FC, ELISA Human
HY-P84785A CHRNA10 Antibody (YA4482)(PBS only) FC, ELISA Human

Related Diseases

Diseases Alias
Tobacco Addiction

  • Nicotine Dependence

  • Tobacco Addiction, Susceptibility To

  • Nicotine Addiction

  • Tobacco Use Disorder

  • Smoking Habit

  • Nicotine Dependence, Protection Against

  • Nicotine Addiction, Protection From

  • Cigarette Habituation

  • Cigarette Habituation, Susceptibility To

  • Smoking Habit, Susceptibility To

  • Nicotine Dependence, Susceptibility To

  • Nicotine Addiction, Susceptibility To

  • Addiction, Tobacco, Susceptibility To

  • Compulsive Tobacco User Syndrome

  • Tobacco Dependence

  • Tobacco Dependence Syndrome

  • Cigarette Addiction

  • Cigarette Dependence

  • Smoking Addiction

  • Smokers Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS02666 CHRNA10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CHRNA10 VGNC VGNC:27323
Felis catus CHRNA10 VGNC VGNC:81999
Mus musculus CHRNA10 MGD MGI:3609260
Macaca mulatta CHRNA10 VGNC VGNC:100914
Canis familiaris CHRNA10 VGNC VGNC:57392
Rattus norvegicus CHRNA10 RGD RGD:620142
Others CHRNA10 NCBI