ELAPOR1 - endosome-lysosome associated apoptosis and autophagy regulator 1 Gene

Also Known as EIG121; KIAA1324

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57535

About ELAPOR1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,114,115-109,206,781 (from NCBI)

This gene has 14 transcripts (splice variants), 206 orthologues and 1 paralogue. Biased expression in stomach (RPKM 32.4), salivary gland (RPKM 26.9) and 13 other tissues.

Summary

Expression of this gene is induced by estrogen and the encoded protein has been characterized as a transmembrane protein. The encoded protein has been found in to correlate with survival in certain carcinomas (PMID: 21102415) and may be important for cellular response to stress (PMID: 21072319). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

ELAPOR1 Products (4)

mRNA Protein Name
NM_001267048.2 NP_001253977.2 endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 2
NM_001284352.2 NP_001271281.1 endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 4
NM_001284353.2 NP_001271282.1 endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 5
NM_020775.5 NP_065826.3 endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
21072319 GOA
involved in cellular response to starvation IMP
IMP: Inferred from mutant phenotype
21072319 GOA
involved in positive regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
21072319 GOA
involved in positive regulation of vacuole organization IMP
IMP: Inferred from mutant phenotype
21072319 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with late endosome IDA
IDA: Inferred from direct assay
21072319 GOA
colocalizes with lysosome IDA
IDA: Inferred from direct assay
21072319 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
21072319 GOA
colocalizes with trans-Golgi network IDA
IDA: Inferred from direct assay
21072319 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endosome/lysosome-associated apoptosis and autophagy regulator 1

  • estrogen-induced gene 121 protein

Recombinant ELAPOR1 Proteins

Cat. No. Product Name Accession Purity
HY-P78759 ELAPOR1 Protein, Human (sf9, His) Q6UXG2 (T42-K910) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Baastrup'S Syndrome

  • Kissing Spine

  • Baastrup Syndrome

  • Kissing Spine, Site Unspecified

  • Osteoarthrosis Interspinalis

  • Overriding Of Dorsal Spinous Processes

  • Localised Idiopathic Skeletal Hyperostosis

  • Baastrup Disease
Estrogen Excess

  • Hyperestrogenism
Female Reproductive Endometrioid Cancer

  • Endometrioid Tumor

  • Endometrioid Neoplasm

  • Female Reproductive Endometrioid Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04293 ELAPOR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ELAPOR1 VGNC VGNC:30567
Rattus norvegicus ELAPOR1 RGD RGD:1310209
Canis familiaris ELAPOR1 VGNC VGNC:42364
Mus musculus ELAPOR1 MGD MGI:1923930
Felis catus ELAPOR1 VGNC VGNC:63095
Others ELAPOR1 NCBI