MS4A7 - membrane spanning 4-domains A7 Gene

Also Known as CFFM4; MS4A8; 4SPAN2; CD20L4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58475

About MS4A7

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,378,532-60,395,948 (from NCBI)

This gene has 12 transcripts (splice variants), 342 orthologues and 16 paralogues. Broad expression in spleen (RPKM 76.0), lung (RPKM 24.9) and 15 other tissues.

Summary

This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of Other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

MS4A7 Products (4)

mRNA Protein Name
NM_021201.5 NP_067024.1 membrane-spanning 4-domains subfamily A member 7 isoform 1
NM_206938.2 NP_996821.1 membrane-spanning 4-domains subfamily A member 7 isoform 2
NM_206939.2 NP_996822.1 membrane-spanning 4-domains subfamily A member 7 isoform 1
NM_206940.2 NP_996823.1 membrane-spanning 4-domains subfamily A member 7 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in trans-Golgi network IDA
IDA: Inferred from direct assay
23874341 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MS4A7 Protein Structure

CD20

CD20: CD20-like family (47 - 207)

  • 0
  • 100
  • 200
  • 240 a.a.
Protein Preferred Names Protein Names

membrane-spanning 4-domains subfamily A member 7

  • CD20 antigen-like 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08702 MS4A4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08705 MS4A7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21656 Ms4a7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28174 Ms4a7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MS4A7 VGNC VGNC:101363
Canis familiaris MS4A7 VGNC VGNC:49673
Rattus norvegicus MS4A7 RGD RGD:1305549
Mus musculus MS4A7 MGD MGI:1918846
Felis catus MS4A7 VGNC VGNC:63632
Others MS4A7 NCBI